{"v":1,"ledgerId":"acrylamide","generatedAt":"2026-11-05T22:49:38.899Z","query":"(TITLE:(\"Acrylamide\" OR \"POLYACRYLAMIDE\" OR \"ACRYLAMIDE MONOMER\" OR \"79-06-1\") OR ABSTRACT:(\"Acrylamide\" OR \"POLYACRYLAMIDE\" OR \"ACRYLAMIDE MONOMER\" OR \"79-06-1\")) AND (TOXICITY OR EXPOSURE OR \"ENDOCRINE\" OR \"REPRODUCTIVE\" OR CARCINOGEN* OR \"BIOMONITORING\" OR \"SYSTEMATIC REVIEW\") AND SRC:MED AND LANG:eng","totalPapers":11968,"lastYearPapers":515,"analysed":10,"byFunding":{"independent":4,"industry":0,"mixed":1,"none_declared":0,"unclear":5},"byDesign":{"human":2,"animal":2,"in_vitro":2,"review":0,"other":4},"byFinding":{"concern":8,"no_effect":1,"mixed":1},"gap":{"independent":{"concern":3,"total":4},"industry":{"concern":0,"total":0}},"fundingSources":{"full_text":3,"grant_metadata":4,"abstract":0,"none":3},"newestPublished":"2026-10-15","papers":[{"id":"pmid:42964665","pmid":"42964665","pmcid":"PMC13720461","doi":"10.1016/j.fochx.2026.104614","title":"Modulation of acrylamide and advanced glycation end products in quinoa and cañihua cookies: Matrix and marker dependent effects of hydrolyzed and unhydrolyzed tara pod phenolic extracts.","journal":"Food chemistry: X","published":"2026-10-15","design":"other","finding":"no_effect","summary":"Hydrolyzed and unhydrolyzed tara pod phenolic extracts influenced acrylamide and advanced glycation end product formation in quinoa and cañihua cookies, keeping acrylamide below EU benchmarks.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"full_text","verified":false},{"id":"pmid:42867173","pmid":"42867173","pmcid":"","doi":"10.1093/ntr/ntag224","title":"Biomarker Evidence of Toxicant Exposure among Blunt and non-Blunt Cigar Smokers.","journal":"Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco","published":"2026-10-13","design":"human_cross_sectional","finding":"concern","summary":"Blunt users exhibited significantly higher urinary concentrations of the acrylamide metabolite AAMA compared with non-blunt cigar users among 8,332 adults in the PATH Study.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42865186","pmid":"42865186","pmcid":"","doi":"10.2174/0113816128485741260930182421","title":"Dietary Acrylamide-Glycidamide Exposure and Metabolic Toxicity: Emerging Evidence in Type 2 Diabetes.","journal":"Current pharmaceutical design","published":"2026-10-07","design":"other","finding":"concern","summary":"A narrative review indicates that dietary acrylamide exposure may impair glucose homeostasis, insulin sensitivity, and pancreatic beta-cell function, contributing to the development of type 2 diabetes.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42888631","pmid":"42888631","pmcid":"PMC13681113","doi":"10.1097/md.0000000000051254","title":"Integrated network toxicology, transcriptomic, and Mendelian randomization analyses explore potential molecular links between acrylamide exposure and clear cell renal cell carcinoma.","journal":"Medicine","published":"2026-10-01","design":"other","finding":"concern","summary":"Network toxicology, transcriptomic, and Mendelian randomization analyses identified potential molecular links and candidate genes, particularly SLC2A1, connecting predicted acrylamide-associated targets with clear cell renal cell carcinoma.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Hospital\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42732660","pmid":"42732660","pmcid":"PMC13590053","doi":"10.1016/j.tranon.2026.103036","title":"Acrylamide-associated gastric cancer progression involves RRM2-related nucleotide metabolic dysregulation and immune evasion.","journal":"Translational 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metabolites.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Horizon 2020\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42613941","pmid":"42613941","pmcid":"","doi":"10.1080/01480545.2026.2718396","title":"Antioxidant efficacy of N-acetylcysteine against acrylamide-induced toxicity in Leydig cells by modulating p53/Bax/Caspase-3 pathway.","journal":"Drug and chemical toxicology","published":"2026-08-18","design":"in_vitro","finding":"concern","summary":"Acrylamide exposure reduced cell viability, elevated oxidative stress, and activated mitochondrial apoptotic pathways in TM3 Leydig cells, effects which were attenuated by N-acetylcysteine.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42731211","pmid":"42731211","pmcid":"PMC13590104","doi":"10.1016/j.psj.2026.107580","title":"Changes in the chick liver structure and blood plasma biochemical properties following in ovo administration of acrylamide.","journal":"Poultry science","published":"2026-08-04","design":"animal","finding":"concern","summary":"In ovo injection of acrylamide decreased hatchability, altered blood biochemical parameters and liver trace elements, and caused negative histomorphometric changes in the liver of one-day-old chicks.","funding":"mixed","conflictOfInterest":false,"fundingEvidence":["industry: \"Ltd. Grzesiakowska-Dul and Students of the Faculty of Animal Science (University of Agriculture in Krakow) for their support\"","public: \"University\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42366942","pmid":"42366942","pmcid":"","doi":"10.1080/09603123.2026.2690596","title":"Exploring the neuroprotective potential of losartan against acrylamide-induced oxidative stress and apoptosis in PC12 cells.","journal":"International journal of environmental health research","published":"2026-06-29","design":"in_vitro","finding":"concern","summary":"Acrylamide induced oxidative stress and apoptotic signaling in PC12 cells, effects that were reversed by pretreatment with losartan.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42341430","pmid":"42341430","pmcid":"","doi":"10.1016/j.tice.2026.103726","title":"Matcha green tea attenuates acrylamide-induced cerebellar damage in rats: Biochemical, histological and immunohistochemical study.","journal":"Tissue & cell","published":"2026-06-23","design":"animal","finding":"concern","summary":"Acrylamide administration caused cerebellar oxidative stress, inflammation, and histological degeneration in male albino rats, which was attenuated by matcha green tea.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false}],"model":"gemini-3.8-flash","run":{"aiCalls":40,"cachedPapers":0,"offTopic":30,"inputTokens":27146,"outputTokens":5036}}