{"v":1,"ledgerId":"bpa","generatedAt":"2026-11-05T20:31:56.187Z","query":"(TITLE:(\"Bisphenol A\" OR \"BISPHENOL A\" OR \"4,4-ISOPROPYLIDENEDIPHENOL\" OR \"80-05-7\") OR ABSTRACT:(\"Bisphenol A\" OR \"BISPHENOL A\" OR \"4,4-ISOPROPYLIDENEDIPHENOL\" OR \"80-05-7\")) AND (TOXICITY OR EXPOSURE OR \"ENDOCRINE\" OR \"REPRODUCTIVE\" OR CARCINOGEN* OR \"BIOMONITORING\" OR \"SYSTEMATIC REVIEW\") AND SRC:MED AND LANG:eng","totalPapers":12373,"lastYearPapers":1030,"analysed":24,"byFunding":{"independent":17,"industry":0,"mixed":0,"none_declared":0,"unclear":7},"byDesign":{"human":2,"animal":8,"in_vitro":4,"review":1,"other":9},"byFinding":{"concern":18,"no_effect":4,"mixed":2},"gap":{"independent":{"concern":12,"total":17},"industry":{"concern":0,"total":0}},"fundingSources":{"full_text":3,"grant_metadata":18,"abstract":0,"none":3},"newestPublished":"2026-11-01","papers":[{"id":"pmid:42951462","pmid":"42951462","pmcid":"","doi":"10.1016/j.tjog.2026.04.019","title":"Protective effects of melatonin against bisphenol A-mediated endometrial tumorigenesis: An experimental study targeting COX-2-dependent MMP-9 expression.","journal":"Taiwanese journal of obstetrics & gynecology","published":"2026-11-01","design":"in_vitro","finding":"concern","summary":"BPA increased proliferation and upregulated COX-2 and MMP-9 expression in human endometrial carcinoma cells, effects that were attenuated by melatonin cotreatment.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42975479","pmid":"42975479","pmcid":"","doi":"10.1021/acs.est.6c12407","title":"Parenteral Nutrition as a Source of Xenobiotic Exposure in Preterm Infants in a Single-Center Case Study.","journal":"Environmental science & technology","published":"2026-11-01","design":"other","finding":"concern","summary":"Analysis of neonatal parenteral nutrition flow-through detected bisphenol A at levels resulting in estimated daily intakes exceeding health-based guidance values and predicted accumulation in preterm infants.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42869360","pmid":"42869360","pmcid":"","doi":"10.1016/j.envres.2026.125889","title":"Biochemical responses of Mytilus galloprovincialis to individual and binary exposures to PFDoA, bisphenol A and tricresyl phosphate: Exposure and post-exposure dynamics.","journal":"Environmental research","published":"2026-10-13","design":"animal","finding":"concern","summary":"Mytilus galloprovincialis exposed to bisphenol A exhibited reduced electron transport system activity and sustained lower aerobic metabolic capacity after a 14-day recovery period.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Regional Agency\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42836715","pmid":"42836715","pmcid":"","doi":"10.1080/19440049.2026.2701456","title":"Aggregate risk assessment of bisphenols A, S, and F among the general Korean population.","journal":"Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment","published":"2026-10-06","design":"other","finding":"no_effect","summary":"An aggregate risk assessment found that bisphenol A, S, and F exposures in the general Korean population are well within health-based guidance values.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Institute of\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42838492","pmid":"42838492","pmcid":"","doi":"10.1016/j.fct.2026.116421","title":"Developmental bisphenol A exposure alters adipose metabolism and lipid remodeling in female mouse offspring.","journal":"Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association","published":"2026-10-06","design":"animal","finding":"concern","summary":"Developmental bisphenol A exposure altered adipose morphology, metabolic gene expression, lipid profiles, and liver parameters predominantly in female mouse offspring.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Province\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42810541","pmid":"42810541","pmcid":"","doi":"10.1016/j.fct.2026.116414","title":"Associations of bisphenol A, F and triclosan with serum lipids: the mediating effect of inflammation and oxidative stress.","journal":"Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association","published":"2026-09-29","design":"human_cross_sectional","finding":"concern","summary":"In 792 adults, urinary bisphenol A was inversely associated with HDL-C and triglycerides and was associated with oxidative stress markers.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"National Natural Science Foundation of China\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42800627","pmid":"42800627","pmcid":"","doi":"10.1016/j.fct.2026.116407","title":"Perinatal BPA exposure-associated depressive-like behaviors in male offspring may involve changes in autophagy-related proteins and GABARAP-GABAAR interaction.","journal":"Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association","published":"2026-09-26","design":"animal","finding":"concern","summary":"Perinatal BPA exposure in mice was associated with depressive-like behaviors, altered hippocampal autophagy markers, reduced GABA and dopamine, and disrupted GABARAP-GABAAR colocalization in male offspring.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Natural Science Foundation\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42790849","pmid":"42790849","pmcid":"","doi":"10.1016/j.envres.2026.125767","title":"First and second trimester concentrations of environmental phenols in association with gestational weight gain in the ECHO cohort.","journal":"Environmental research","published":"2026-09-25","design":"human_cohort","finding":"mixed","summary":"First-trimester urinary concentrations of BPA and other phenols were associated with greater gestational weight gain in the ECHO cohort, whereas second-trimester associations were generally null.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"NIH\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42772441","pmid":"42772441","pmcid":"","doi":"10.1016/j.envpol.2026.129209","title":"Network pharmacology and molecular docking-based investigation on the mechanism of BPA in depression and experimental verification in offspring mice.","journal":"Environmental pollution (Barking, Essex : 1987)","published":"2026-09-22","design":"other","finding":"concern","summary":"Urinary BPA was positively associated with depression scores in humans, and BPA exposure induced depression-like behaviors and neuroinflammation in offspring mice.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Education Department\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42710794","pmid":"42710794","pmcid":"","doi":"10.1016/j.cbpc.2026.110690","title":"Environmental BPA exposure promotes flavivirus replication and extends mosquito lifespan.","journal":"Comparative biochemistry and physiology. Toxicology & pharmacology : CBP","published":"2026-09-08","design":"animal","finding":"concern","summary":"Chronic larval exposure to bisphenol A enhanced Zika and Dengue virus replication and extended the lifespan of infected Aedes aegypti mosquitoes by modulating oxidative stress responses.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42679520","pmid":"42679520","pmcid":"","doi":"10.1016/j.marpolbul.2026.120308","title":"From embryo to sexual maturity: chronic BPA exposure under elevated contamination scenarios induces multi-organ toxicity in marine medaka (Oryzias melastigma).","journal":"Marine pollution bulletin","published":"2026-09-01","design":"animal","finding":"concern","summary":"Chronic exposure to Bisphenol A from embryo to maturity caused developmental, behavioral, histopathological, antioxidant, gene expression, and intestinal microbiota alterations in marine medaka.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"National Natural Science Foundation of China\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42668130","pmid":"42668130","pmcid":"","doi":"10.1016/j.envpol.2026.129026","title":"Aggregated exposure to bisphenol A in China: A holistic risk assessment via oral, dermal, and inhalation routes.","journal":"Environmental pollution (Barking, Essex : 1987)","published":"2026-08-29","design":"other","finding":"no_effect","summary":"Aggregated BPA exposure levels across oral, dermal, and inhalation routes in the Chinese population were below the temporary tolerable daily intake, suggesting low health risk.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Department of Science and Technology\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42641455","pmid":"42641455","pmcid":"","doi":"10.1016/j.marpolbul.2026.120274","title":"Occurrence and ecological risks of microplastics and bisphenol A in a coastal receiving environment affected by wastewater from a large-scale plastic production enterprise.","journal":"Marine pollution bulletin","published":"2026-08-25","design":"other","finding":"concern","summary":"Microplastics carrying elevated concentrations of bisphenol A were found downstream from a plastic production enterprise, posing potential ecological risks in coastal waters.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Science and Technology Commission\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42636645","pmid":"42636645","pmcid":"","doi":"10.1016/j.marpolbul.2026.120287","title":"Aged polystyrene nanoplastics and bisphenol A co-exposure impair mitochondrial respiration in juvenile horseshoe crab Tachypleus tridentatus.","journal":"Marine pollution bulletin","published":"2026-08-24","design":"animal","finding":"concern","summary":"Exposure to bisphenol A alone and combined with pristine or aged polystyrene nanoplastics impaired mitochondrial respiration and increased oxidative stress markers in juvenile Chinese horseshoe crabs.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Natural Science Foundation\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42628448","pmid":"42628448","pmcid":"","doi":"10.1016/j.talanta.2026.130488","title":"Target quantification and ion mobility-HRMS suspect screening of BPA and its alternatives in human urine.","journal":"Talanta","published":"2026-08-20","design":"other","finding":"no_effect","summary":"A UHPLC-MS/MS and IM-HRMS method was developed to quantify and screen BPA and alternative bisphenols in urine, detecting widespread exposure in 25 healthy volunteers.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42617814","pmid":"42617814","pmcid":"","doi":"10.1016/j.biortech.2026.135674","title":"Biodegradation and toxicity attenuation of bisphenol A by Sphingopyxis granuli XYQ201: mechanism elucidation and wastewater application.","journal":"Bioresource technology","published":"2026-08-19","design":"in_vitro","finding":"concern","summary":"Sphingopyxis granuli XYQ201 degraded bisphenol A into hydroxylated metabolites that exhibited markedly lower estrogenic activity in a recombinant yeast bioreporter assay.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"National Natural Science Foundation of China\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42520954","pmid":"42520954","pmcid":"","doi":"10.1016/j.yrtph.2026.106193","title":"Prioritizing emerging contaminants in tropical riverine systems: An integrated approach using ecological and human health risk indices.","journal":"Regulatory toxicology and pharmacology : RTP","published":"2026-07-29","design":"other","finding":"concern","summary":"Bisphenol A was detected in Malaysian rivers at concentrations up to 837 ng/L and prioritized as a high-concern contaminant using ecological and health risk indices.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Ministry of\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42523831","pmid":"42523831","pmcid":"","doi":"10.1007/s40201-026-00993-1","title":"Occurrence, human health and ecological risk assessment of bisphenol A in the estuarine water and the edible fish species from the northwest of the Persian Gulf, Iran (Bandar-e Mahshahr).","journal":"Journal of environmental health science & engineering","published":"2026-07-27","design":"other","finding":"no_effect","summary":"BPA was detected in estuarine water and edible fish from Bandar-e Mahshahr, Iran, but risk assessments indicated low non-carcinogenic human health and ecological risks.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42404493","pmid":"42404493","pmcid":"PMC13330514","doi":"10.1016/j.toxrep.2026.102305","title":"Cross-study analysis identifies estrogen depletion and exposure duration as key determinants of bisphenol A transcriptomic potency in MCF-7 cells.","journal":"Toxicology reports","published":"2026-06-27","design":"in_vitro","finding":"concern","summary":"Cross-study analysis showed reproducible transcriptomic points of departure for bisphenol A in MCF-7 cells, with potency estimates influenced by estrogen depletion and exposure duration.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42163470","pmid":"42163470","pmcid":"PMC13727354","doi":"10.1002/jat.70248","title":"Bisphenol Analog-Induced Cytotoxicity: Unraveling Endoplasmic Reticulum (ER) Stress and Apoptotic Pathways.","journal":"Journal of applied toxicology : JAT","published":"2026-05-20","design":"in_vitro","finding":"concern","summary":"Exposure to BPA and its analogs induced endoplasmic reticulum stress and apoptosis-related responses in human intestinal, hepatic, and microglial cell lines.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42009370","pmid":"42009370","pmcid":"","doi":"10.1002/jat.70210","title":"Comparative Dose-Dependent Effects of Bisphenol A, F, and S on Testicular Oxidative Stress, DNA Damage, and Reproductive Hormones in Rats.","journal":"Journal of applied toxicology : JAT","published":"2026-04-20","design":"animal","finding":"concern","summary":"Exposure of male rats to BPA, BPS, and BPF induced DNA damage, altered oxidative stress parameters, and decreased testosterone levels.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:41967509","pmid":"41967509","pmcid":"","doi":"10.1002/jat.70195","title":"Association Between Bisphenol A Exposure and Declining Sperm Quality and Its Potential Mechanism: A Systematic Review and Meta-Analysis Based on the Evidence of Epidemiological and Rodent Studies.","journal":"Journal of applied toxicology : JAT","published":"2026-04-12","design":"systematic_review","finding":"mixed","summary":"A systematic review and meta-analysis found BPA exposure was negatively correlated with sperm quality in rodent studies, but showed no association in epidemiological studies.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"National Natural Science Foundation of China\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42633102","pmid":"42633102","pmcid":"PMC13499062","doi":"10.1016/j.ibneur.2026.01.015","title":"Behavioural, neurochemical, and neurohistological effects of bisphenol A and vanadium following chronic co-administration in mice.","journal":"IBRO neuroscience reports","published":"2026-02-04","design":"animal","finding":"concern","summary":"Oral co-exposure to bisphenol A and vanadium for 56 days exacerbated behavioral, neurochemical, and histological impairments including neuronal cell death in the prefrontal cortex of male mice.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"full_text","verified":false},{"id":"pmid:42437265","pmid":"42437265","pmcid":"PMC13355015","doi":"10.1016/j.toxrep.2025.102167","title":"Network toxicology and molecular docking reveal the mechanistic basis of bisphenol A-mediated cholestatic liver injury.","journal":"Toxicology reports","published":"2025-11-15","design":"other","finding":"concern","summary":"Network toxicology and molecular docking analyses identified common genes, pathways, and binding affinities linking bisphenol A exposure to cholestatic liver injury.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"National Natural Science Foundation of China\""],"fundingSource":"full_text","verified":false}],"substitution":{"claim":"BPA-free","original":{"label":"BPA","papers":17800},"replacements":[{"label":"BPS","papers":1499},{"label":"BPF","papers":1033}]},"model":"gemini-3.8-flash","run":{"aiCalls":0,"cachedPapers":40,"offTopic":16,"inputTokens":0,"outputTokens":0}}