{"v":1,"ledgerId":"chlorpyrifos","generatedAt":"2026-11-05T22:13:27.069Z","query":"(TITLE:(\"Chlorpyrifos\" OR \"CHLORPYRIFOS\" OR \"CHLORPYRIFOS-METHYL\" OR \"2921-88-2\") OR ABSTRACT:(\"Chlorpyrifos\" OR \"CHLORPYRIFOS\" OR \"CHLORPYRIFOS-METHYL\" OR \"2921-88-2\")) AND (TOXICITY OR EXPOSURE OR \"ENDOCRINE\" OR \"REPRODUCTIVE\" OR CARCINOGEN* OR \"BIOMONITORING\" OR \"SYSTEMATIC REVIEW\") AND SRC:MED AND LANG:eng","totalPapers":4436,"lastYearPapers":232,"analysed":29,"byFunding":{"independent":16,"industry":0,"mixed":0,"none_declared":1,"unclear":12},"byDesign":{"human":2,"animal":14,"in_vitro":6,"review":1,"other":6},"byFinding":{"concern":23,"no_effect":5,"mixed":1},"gap":{"independent":{"concern":15,"total":16},"industry":{"concern":0,"total":0}},"fundingSources":{"full_text":7,"grant_metadata":15,"abstract":0,"none":7},"newestPublished":"2026-11-01","papers":[{"id":"pmid:42808833","pmid":"42808833","pmcid":"PMC13621938","doi":"10.1002/vms3.71230","title":"Integrated Biomarker Assessment of Bifenthrin, Chlorpyrifos and Endosulfan Toxicity in Indigenous Carps (Catla catla and Labeo rohita): Oxidative Stress, Genotoxicity and Nuclear Alterations.","journal":"Veterinary medicine and science","published":"2026-11-01","design":"animal","finding":"concern","summary":"Exposure to bifenthrin and chlorpyrifos mixtures induced oxidative stress, DNA damage, and nuclear abnormalities in Catla catla and Labeo rohita.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University, Riyadh, SaudiArabia ORF‐2026‐591 This study was supported by King Saud University, Riyadh, SaudiArabia (ORF‐2026‐591) to the Ongoing Research Fund\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42933345","pmid":"42933345","pmcid":"","doi":"10.1016/j.ecoenv.2026.120975","title":"Divergent horizontal transfer of insecticides in a social termite.","journal":"Ecotoxicology and environmental safety","published":"2026-10-26","design":"animal","finding":"concern","summary":"In Coptotermes formosanus, chlorpyrifos showed high acute toxicity and rapid donor mortality but resulted in weak horizontal transfer to nestmates compared to other insecticides.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"National Natural Science Foundation of China\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42925416","pmid":"42925416","pmcid":"PMC13695688","doi":"10.1007/s00431-026-07546-6","title":"Pesticide detection in postmortem serum, hair, and cerebrospinal fluid from cases of sudden unexpected death in infancy: a registry-based study.","journal":"European journal of pediatrics","published":"2026-10-24","design":"human_cross_sectional","finding":"concern","summary":"Pesticides including chlorpyrifos were detected in post-mortem hair, serum, and cerebrospinal fluid from infants who died of sudden unexpected death in infancy.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"full_text","verified":false},{"id":"pmid:42962623","pmid":"42962623","pmcid":"","doi":"10.1016/j.talanta.2026.130806","title":"Quantification of multi-class pesticides in wipes dust by liquid chromatography - mass spectrometry: development and application in rural households.","journal":"Talanta","published":"2026-10-24","design":"other","finding":"no_effect","summary":"A liquid chromatography-mass spectrometry method was developed to quantify pesticides in wipe dust, frequently detecting chlorpyrifos, imidacloprid, and azoxystrobin in rural French homes.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42918440","pmid":"42918440","pmcid":"","doi":"10.1016/j.yrtph.2026.106282","title":"Pesticide residues in common vegetables: A probabilistic risk assessment using Monte Carlo simulation for adult and child consumers.","journal":"Regulatory toxicology and pharmacology : RTP","published":"2026-10-23","design":"other","finding":"no_effect","summary":"Dietary risk assessment of vegetable pesticide residues in Iran found chlorpyrifos produced the highest hazard quotients, but all values remained well below the safety threshold of 1.0.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42911460","pmid":"42911460","pmcid":"","doi":"10.1007/s10646-026-03182-w","title":"Combined toxicity of chlorpyrifos and nanoplastics in the marine amphipod Parhyale hawaiensis: implications for chlorpyrifos risk assessment in Latin American coasts.","journal":"Ecotoxicology (London, England)","published":"2026-10-22","design":"animal","finding":"concern","summary":"Chlorpyrifos alone and combined with polyethylene nanoplastics caused mortality and immobility in neonate Parhyale hawaiensis over 96-hour exposures, with co-exposure altering toxicity.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42888840","pmid":"42888840","pmcid":"","doi":"10.1002/jat.70464","title":"Toxicity of Organophosphate Insecticides and Biochemical Mechanisms Associated With Resistance in Field Populations of Plutella xylostella (L.) From Kashmir, India.","journal":"Journal of applied toxicology : JAT","published":"2026-10-16","design":"animal","finding":"mixed","summary":"Field populations of Plutella xylostella from Kashmir exhibited varying resistance to chlorpyrifos, dimethoate, and quinalphos, with elevated AChE and CYP450 activities in resistant populations.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42838471","pmid":"42838471","pmcid":"","doi":"10.1016/j.dci.2026.105745","title":"Dietary cinnamaldehyde alleviates chlorpyrifos-induced immunotoxicity in Nile tilapia and modulates apoptosis-, autophagy-, and AKT/mTOR-related gene expression.","journal":"Developmental and comparative immunology","published":"2026-10-06","design":"animal","finding":"concern","summary":"Chronic waterborne chlorpyrifos exposure in Nile tilapia induced hematological disturbances, immunosuppression, splenic oxidative injury, gene dysregulation, and histopathological lesions, which were alleviated by dietary cinnamaldehyde.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42830456","pmid":"42830456","pmcid":"","doi":"10.1093/etojnl/vgag262","title":"The risk posed by exposure to pesticides through beeswax to adult western honey bees (Apis mellifera).","journal":"Environmental toxicology and chemistry","published":"2026-10-03","design":"animal","finding":"no_effect","summary":"Chlorpyrifos and other tested pesticides in beeswax did not pose a significant risk to honey bee survival at concentrations reported in the literature.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Institute of\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42905957","pmid":"42905957","pmcid":"PMC13686550","doi":"10.1111/ele.70459","title":"Eco-Evolutionary Feedback to a Pesticide Worsens the Impact of a Pesticide Switch in a Pivotal Freshwater Non-Target Species.","journal":"Ecology letters","published":"2026-10-01","design":"animal","finding":"concern","summary":"Chlorpyrifos exposure in Daphnia magna altered genotype composition and richness, conferring tolerance to organophosphates but increasing vulnerability to subsequent deltamethrin exposure.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"full_text","verified":false},{"id":"pmid:42917003","pmid":"42917003","pmcid":"","doi":"10.1021/acs.est.6c07908","title":"Bioenergetics Underpins Both Heat-Pesticide Synergisms and Their Transgenerational Offsetting in Water Fleas.","journal":"Environmental science & technology","published":"2026-10-01","design":"animal","finding":"concern","summary":"Exposure to chlorpyrifos and heat reduced body size, growth, and energy budgets in Daphnia magna within generations, while parental exposure induced transgenerational mitigation in grand-offspring.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Ministry of\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42815868","pmid":"42815868","pmcid":"","doi":"10.1016/j.cbpc.2026.110706","title":"Dermal exposure represents a major pathway of chlorpyrifos uptake in insectivorous bats: Insights from a toxicokinetic model.","journal":"Comparative biochemistry and physiology. Toxicology & pharmacology : CBP","published":"2026-09-30","design":"other","finding":"concern","summary":"A toxicokinetic model shows dermal exposure is a major pathway for chlorpyrifos uptake in the bat Eptesicus fuscus, exceeding predicted uptake in rats.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Ministry of\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42815327","pmid":"42815327","pmcid":"","doi":"10.1016/j.ecoenv.2026.120848","title":"Chlorpyrifos and its metabolite 3,5,6-trichloro-2-pyridinol elicit MASLD-related lipid metabolic perturbations in HepG2 cells.","journal":"Ecotoxicology and environmental safety","published":"2026-09-30","design":"in_vitro","finding":"concern","summary":"Chlorpyrifos and its metabolite 3,5,6-trichloro-2-pyridinol, individually and combined, promoted lipid accumulation, altered lipidomic and transcriptomic profiles, and disrupted cellular energy and redox homeostasis in HepG2 cells.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42801970","pmid":"42801970","pmcid":"","doi":"10.1016/j.jinsphys.2026.105070","title":"Combined imidacloprid and chlorpyrifos disrupt gut microbiota-host interactions and reduced performance and survival in honey bees.","journal":"Journal of insect physiology","published":"2026-09-27","design":"animal","finding":"concern","summary":"Combined exposure to chlorpyrifos and imidacloprid caused gut dysbiosis, midgut structural damage, suppressed detoxification enzymes, and reduced body weight and survival in honey bees.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"National Natural Science Foundation of China\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42789046","pmid":"42789046","pmcid":"","doi":"10.1007/s00210-026-05943-0","title":"Syringic acid attenuates chlorpyrifos-induced redox imbalance, mitochondrial depolarization, and apoptosis-related transcriptional changes in HepG2 cells.","journal":"Naunyn-Schmiedeberg's archives of pharmacology","published":"2026-09-25","design":"in_vitro","finding":"concern","summary":"Chlorpyrifos exposure in HepG2 cells reduced metabolic activity, increased oxidative stress and mitochondrial depolarization, and altered stress-related gene expression, which were attenuated by syringic acid.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42789760","pmid":"42789760","pmcid":"","doi":"10.1093/etojnl/vgag258","title":"Species-specific sensitivity to in vitro inhibition of the thyroperoxidase (TPO) enzyme by environmental pollutants for five fishes.","journal":"Environmental toxicology and chemistry","published":"2026-09-25","design":"in_vitro","finding":"concern","summary":"Triclocarban inhibited thyroperoxidase enzyme activity across five phylogenetically diverse fish species in an in vitro assay.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42931626","pmid":"42931626","pmcid":"PMC13709529","doi":"10.3390/toxics14100839","title":"Potential of <i>Pycnoporus sanguineus</i> (NUOL-PPK.02) for Bioremediation of Chlorpyrifos and Azoxystrobin in an Autoclaved Soil-Based Biomixture: A Pot Incubation Study.","journal":"Toxics","published":"2026-09-22","design":"other","finding":"concern","summary":"Pycnoporus sanguineus inoculation showed limited dissipation of chlorpyrifos in a soil-based biomixture, and chlorpyrifos exposure inhibited fungal mycelial growth by up to 51%.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University https://ror.org/03cq4gr50 Fundamental Fund (FF) National Science, Research and Innovation Fund or NSRF, Thailand 218494 This study was supported by the Integrated Land and Water Resources Management Research and Development Centre in Northeast Thailand, Khon Kaen University, Thailand, and the Fundamental Fund (FF), fiscal year 2026 (Project No. 218494), Khon Kaen University, from the National Science, Research and Innovation Fund or NSRF, Thailand. Acknowledgments The authors gratefully acknowledge the Integrated Land and Water Resources Management Research and Development Center in Northeast Thailand, Khon Kaen University, and the Research Developing and Learning Center on Earthworm for Agriculture and Environment (VermiTech@KKU), Khon Kaen University, Thailand, for providing support and research facilities. National Science, Research and Innovation Fund\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42772167","pmid":"42772167","pmcid":"","doi":"10.1016/j.envint.2026.110531","title":"Mixture risk assessment of pesticides with acute neurotoxic effects: a novel approach based on urinary exposure biomarkers.","journal":"Environment international","published":"2026-09-20","design":"other","finding":"concern","summary":"A mixture risk assessment using European biomonitoring data found margins of exposure below safety thresholds for neurotoxic pesticides, identifying chlorpyrifos and other organophosphates as primary risk drivers.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"European Commission\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42797739","pmid":"42797739","pmcid":"PMC13611267","doi":"10.3390/toxics14090820","title":"Prenatal Chlorpyrifos Exposure Induces Ovarian Toxicity in Rat Offspring: Modulatory Potential of Curcumin.","journal":"Toxics","published":"2026-09-15","design":"animal","finding":"concern","summary":"Prenatal chlorpyrifos exposure in rats altered ovarian structure, reduced follicle counts, and induced biochemical changes in female offspring, with partial modulation by curcumin.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42732734","pmid":"42732734","pmcid":"","doi":"10.1016/j.ecoenv.2026.120769","title":"A single exposure to an organophosphate insecticide disrupts developmental patterns of hippocampal cell proliferation and overall brain size in a migratory songbird.","journal":"Ecotoxicology and environmental safety","published":"2026-09-13","design":"animal","finding":"concern","summary":"A single sublethal chlorpyrifos exposure in starling nestlings altered developmental trajectories of hippocampal cell proliferation and increased telencephalon volume.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Research Council\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42726160","pmid":"42726160","pmcid":"","doi":"10.1007/s11274-026-05238-9","title":"Biodegradation of chlorpyrifos, cypermethrin, and lindane by pesticide-tolerant hexa-bacterial consortia with integrated plant growth promoting and biosurfactant production potential.","journal":"World journal of microbiology & biotechnology","published":"2026-09-11","design":"in_vitro","finding":"no_effect","summary":"Hexa-bacterial consortia producing biosurfactants effectively degraded chlorpyrifos, cypermethrin, and lindane in culture and pesticide-amended soil, yielding non-toxic metabolites.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42795555","pmid":"42795555","pmcid":"PMC13609906","doi":"10.3390/microorganisms14091974","title":"Metabolite-Resolved Validation of Bacterial Organophosphate Transformation in Soil: A Critical Review of Selected Organophosphate Case Studies.","journal":"Microorganisms","published":"2026-09-07","design":"systematic_review","finding":"no_effect","summary":"A structured review evaluated evidence on bacterial transformation pathways, metabolite resolution, and soil bioremediation feasibility for chlorpyrifos and five other organophosphate pesticides.","funding":"none_declared","conflictOfInterest":false,"fundingEvidence":["none: \"This research received no\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42700388","pmid":"42700388","pmcid":"","doi":"10.1080/03601234.2026.2727284","title":"Differential transcription of the ascorbate peroxidase gene (<i>FsAPX</i>) in the freshwater diatom <i>Fragilaria saxoplanctonica</i> under metals and pesticides and its environmental implications.","journal":"Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes","published":"2026-09-05","design":"in_vitro","finding":"concern","summary":"Exposure to chlorpyrifos increased FsAPX expression and reactive oxygen species while decreasing chlorophyll autofluorescence in the freshwater diatom Fragilaria saxoplanctonica.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42737773","pmid":"42737773","pmcid":"PMC13566142","doi":"10.3390/ijms27177876","title":"Detoxifying Effects of a Phenolic-Rich <i>Thunbergia laurifolia</i> Water Extract Against Chlorpyrifos-Induced Oxidative Stress: Evidence from an Integrated In Vitro and In Vivo Study.","journal":"International journal of molecular sciences","published":"2026-09-03","design":"animal","finding":"concern","summary":"Thunbergia laurifolia water extract restored acetylcholinesterase activity and reduced oxidative stress markers in chlorpyrifos-exposed rats.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42665249","pmid":"42665249","pmcid":"","doi":"10.1016/j.envres.2026.125579","title":"Pesticide bioaccumulation in fish from an agricultural watershed: Patterns, drivers, and implications for monitoring.","journal":"Environmental research","published":"2026-08-28","design":"other","finding":"concern","summary":"Chlorpyrifos and other organophosphates were among the most frequently detected and concentrated pesticides bioaccumulating in wild fish collected from an agricultural watershed in Uruguay.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42624385","pmid":"42624385","pmcid":"","doi":"10.1016/j.reprotox.2026.109330","title":"Chlorpyrifos exposure remodels the spermatogenic niche and alters testicular epigenetic dynamics in the absence of overt reproductive toxicity.","journal":"Reproductive toxicology (Elmsford, N.Y.)","published":"2026-08-20","design":"animal","finding":"concern","summary":"Chronic chlorpyrifos exposure in mice remodeled the spermatogenic niche, dysregulated Sertoli cell function, and altered testicular epigenetic dynamics without overt reproductive toxicity.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Ministry of\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42852043","pmid":"42852043","pmcid":"","doi":"10.1021/ehp.6c00319","title":"A Pilot Study to Explore the Application of Silicone Wristband-Based Chemical Exposure Assessment to Kidney Disease Epidemiology in Agricultural Workers.","journal":"Environmental health perspectives","published":"2026-08-20","design":"human_cross_sectional","finding":"concern","summary":"In a study of 43 male agricultural workers, higher chlorpyrifos levels on silicone wristbands were associated with an increased prevalence of reduced kidney function.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"NIEHS\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42600970","pmid":"42600970","pmcid":"","doi":"10.1016/j.cbi.2026.112291","title":"Endoplasmic reticulum stress is involved in chronic chlorpyrifos-induced jejunal barrier injury in weaned mice.","journal":"Chemico-biological interactions","published":"2026-08-14","design":"animal","finding":"concern","summary":"Chronic chlorpyrifos exposure via drinking water caused jejunal epithelial barrier injury and endoplasmic reticulum stress in weaned mice and intestinal cell models.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"National Natural Science Foundation of China\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42697644","pmid":"42697644","pmcid":"","doi":"10.1016/j.pestbp.2026.107266","title":"Chlorpyrifos exposure induces inflammatory and immune dysregulation: An integrative in silico and in vitro analysis.","journal":"Pesticide biochemistry and physiology","published":"2026-07-25","design":"in_vitro","finding":"concern","summary":"Chlorpyrifos exposure promoted inflammatory activation in RAW264.7 macrophages via activation of p38 MAPK and NF-κB p65 signaling pathways.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"grant_metadata","verified":false}],"model":"gemini-3.8-flash","run":{"aiCalls":37,"cachedPapers":2,"offTopic":10,"inputTokens":25671,"outputTokens":5060}}