{"v":1,"ledgerId":"formaldehyde-releasers","generatedAt":"2026-11-05T21:23:49.102Z","query":"(TITLE:(\"Formaldehyde\" OR \"DMDM HYDANTOIN\" OR \"IMIDAZOLIDINYL UREA\" OR \"DIAZOLIDINYL UREA\" OR \"6440-58-0\") OR ABSTRACT:(\"Formaldehyde\" OR \"DMDM HYDANTOIN\" OR \"IMIDAZOLIDINYL UREA\" OR \"DIAZOLIDINYL UREA\" OR \"6440-58-0\")) AND (TOXICITY OR EXPOSURE OR \"ENDOCRINE\" OR \"REPRODUCTIVE\" OR CARCINOGEN* OR \"BIOMONITORING\" OR \"SYSTEMATIC REVIEW\") AND SRC:MED AND LANG:eng","totalPapers":7220,"lastYearPapers":420,"analysed":15,"byFunding":{"independent":6,"industry":0,"mixed":1,"none_declared":1,"unclear":7},"byDesign":{"human":4,"animal":1,"in_vitro":2,"review":1,"other":7},"byFinding":{"concern":9,"no_effect":4,"mixed":2},"gap":{"independent":{"concern":3,"total":6},"industry":{"concern":0,"total":0}},"fundingSources":{"full_text":6,"grant_metadata":4,"abstract":0,"none":5},"newestPublished":"2026-11-01","papers":[{"id":"pmid:42975470","pmid":"42975470","pmcid":"","doi":"10.1021/acs.est.6c03632","title":"Regional Impacts of Unconventional Oil and Gas Operations on Ozone and Air Toxics.","journal":"Environmental science & technology","published":"2026-11-01","design":"other","finding":"concern","summary":"Air quality modeling demonstrates that unconventional oil and gas development increases population-weighted annual average ambient formaldehyde concentrations across the continental United States.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42962645","pmid":"42962645","pmcid":"","doi":"10.1016/j.jhazmat.2026.144059","title":"Construction and application of a mouth level exposure assessment system for harmful constituents in cigarette and heated tobacco products.","journal":"Journal of hazardous materials","published":"2026-10-28","design":"human_cross_sectional","finding":"mixed","summary":"A mouth level exposure model showed formaldehyde exposure was reduced by over 90% in heated tobacco product users compared to regular cigarette users.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42913006","pmid":"42913006","pmcid":"PMC13693651","doi":"10.1126/sciadv.aea1431","title":"NRF2 coordinates cystine import and glutathione use to sustain ferroptosis resistance and formaldehyde tolerance in cancer.","journal":"Science advances","published":"2026-10-23","design":"in_vitro","finding":"concern","summary":"NRF2 coordinates formaldehyde tolerance and ferroptosis resistance in cancer cells through SLC7A11 up-regulation, which forms a cysteine-derived thiazolidine conjugate.","funding":"mixed","conflictOfInterest":false,"fundingEvidence":["industry: \"funded by MCIN/AEI/10.13039/501100011033 grant PID2022-136694NB-I00 (“ERDF A way of making Europe”) and grant RYC2021-032395-I (“European Union NextGenerationEU/PRTR”). L.B.P. acknowledges funding from the Deutsche José Carreras Leukämie-Stiftung (DJCLS 04 R/2023) and from Departament de Recerca i Universitats/Generalitat de Catalunya (AGAUR 2021SGR01309). G.R.’s lab was supported by PID2021-123039OB634C21 and by AGAUR 2021SGR01535. M.P. and L.P.-P. were supported by Programa Investigo (AGAUR) funded by Next Generation EU - PRTR [2023 INV-2 00011 (200011TC5 and 200011TC3)]. A.E.M. and C.U. were funded by CONICET PhD fellowships. N.A.-A. acknowledges 101081347-CarrerasLeaders-HORIZON-MSCA-2021-COFUND-01. R.J.H. and D.J.L.J.’s lab contributions were supported by a New Investigator Award from the Engineering and Physical Sciences Research Council, UK (EP/T033460/1, R.J.H.), a Leverhulme Trust Research Project Grant (RPG-2024-303, R.J.H.), the John and Lucille van Geest Foundation, and the National Institute for Health Research Leicester Biomedical Research Centre (D.J.L.J.). A.E.M. and C.U. acknowledge The Company\"","public: \"Horizon Europe\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42899692","pmid":"42899692","pmcid":"","doi":"10.1093/ntr/ntag228","title":"Tobacco Composition, Nicotine, and Carbonyl Emissions Across IQOS Product Generations: ILUMA/TEREA Compared with IQOS 2.4/HEETS.","journal":"Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco","published":"2026-10-20","design":"other","finding":"concern","summary":"Mainstream aerosol analysis showed formaldehyde yields were significantly higher from IQOS ILUMA/TEREA sticks compared to IQOS 2.4/HEETS sticks.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42886610","pmid":"42886610","pmcid":"","doi":"10.1159/iaa/adfag037","title":"Optimizing emergency management of anaphylaxis in dentistry: a systematic review of current practices.","journal":"International archives of allergy and immunology","published":"2026-10-16","design":"systematic_review","finding":"concern","summary":"A systematic review identified dental materials, primarily formaldehyde, as the leading trigger of anaphylaxis cases in dental practice.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42944341","pmid":"42944341","pmcid":"PMC13709226","doi":"10.3390/s26206478","title":"Estimating Life Expectancy in the U.S.: Identifying Environmental Determinants and Disparities (2003 to 2019).","journal":"Sensors (Basel, Switzerland)","published":"2026-10-13","design":"other","finding":"concern","summary":"A machine learning study of US data (2003-2019) indicates that reducing environmental pollutants, including formaldehyde, could potentially increase life expectancy for children under one year of age.","funding":"none_declared","conflictOfInterest":false,"fundingEvidence":["none: \"This research received no\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42892262","pmid":"42892262","pmcid":"","doi":"10.1016/j.envint.2026.110558","title":"Identification of priority gaseous component in biodiesel exhaust and its potential pulmonary hazards: a data-driven screening and validation strategy.","journal":"Environment international","published":"2026-10-12","design":"other","finding":"concern","summary":"Formaldehyde was identified as a key component in biodiesel exhaust gas driving pulmonary fibrogenic toxicity and epithelial-mesenchymal transition via TGF-β1 mediation in experimental validations.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"National Natural Science Foundation of China\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42854493","pmid":"42854493","pmcid":"PMC13677759","doi":"10.1016/j.psj.2026.107907","title":"Effects of three feed disinfectants on microbial population and nutritional value of broiler diets.","journal":"Poultry science","published":"2026-10-05","design":"animal","finding":"no_effect","summary":"Premix application of formaldehyde and formaldehyde-propionic acid feed disinfectants improved broiler growth performance and feed hygienic quality without compromising diet nutritional value.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42829561","pmid":"42829561","pmcid":"PMC13633472","doi":"10.1029/2026gh001910","title":"Global Health Hazards From Human-Derived Volatile Organic Compounds Amid Emission Variability.","journal":"GeoHealth","published":"2026-10-03","design":"other","finding":"concern","summary":"Chemistry-climate simulations show ambient formaldehyde and other VOC exposures present non-carcinogenic health hazards, with formaldehyde exhibiting hazard quotients ranging from 1.4 to 2.0.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42663173","pmid":"42663173","pmcid":"PMC13523080","doi":"10.1002/hpja.70241","title":"A Geospatial Linkage Analysis of Environmental Exposures, Socioeconomic Profile and Health Outcomes Among Women of Reproductive Age in Victoria, Australia.","journal":"Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals","published":"2026-10-01","design":"human_cross_sectional","finding":"no_effect","summary":"A geospatial linkage analysis in Victoria, Australia found weak associations between environmental exposures including formaldehyde and non-communicable disorders among women of reproductive age.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University of Melbourne Early Career Research Grant; 2026 Climate Change Accelerator Grant\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42915705","pmid":"42915705","pmcid":"PMC13647981","doi":"10.1021/acs.analchem.6c01478","title":"Effects of Chemical Fixation on Stimulated Raman Scattering Microscopy.","journal":"Analytical chemistry","published":"2026-10-01","design":"in_vitro","finding":"no_effect","summary":"Formaldehyde-based fixatives caused minimal disruption to spatial or spectral biomolecular features in HeLa cells during stimulated Raman scattering microscopy compared to other fixatives.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"European Union\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42747024","pmid":"42747024","pmcid":"","doi":"10.1097/xcs.0000000000001943","title":"Differences in the Effectiveness of Smoke Evacuator Types for Reducing Surgical Smoke: A Randomized Controlled Trial.","journal":"Journal of the American College of Surgeons","published":"2026-09-16","design":"human_rct","finding":"no_effect","summary":"A randomized controlled trial showed electrocautery-incorporated smoke evacuation significantly reduced surgical smoke particle counts and volatile organic compound levels compared with hose-type evacuation during laparotomy.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42780313","pmid":"42780313","pmcid":"PMC13597205","doi":"10.1016/j.eehl.2026.100280","title":"Global warming amplifies atmospheric formaldehyde exposure and widens spatial inequality.","journal":"Eco-Environment & Health","published":"2026-09-01","design":"other","finding":"concern","summary":"Climate warming is projected to increase ambient formaldehyde concentrations globally, substantially expanding population exposure and cancer-related health concerns, particularly in low Human Development Index regions.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"National Natural Science Foundation of China\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42397578","pmid":"42397578","pmcid":"PMC13694579","doi":"10.1007/s00204-026-04489-7","title":"Scientific approach to derive occupational exposure limits for formaldehyde releasers.","journal":"Archives of toxicology","published":"2026-07-03","design":"other","finding":"concern","summary":"The MAK Commission developed a framework based on hydrolysis rates and vapor pressure to establish carcinogen classifications and occupational exposure limits for formaldehyde releasers.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Deutsche Forschungsgemeinschaft\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42209715","pmid":"42209715","pmcid":"PMC13727692","doi":"10.1038/s41370-026-00883-6","title":"Facility-wide assessment of occupational exposure to dust, noise, and formaldehyde.","journal":"Journal of exposure science & environmental epidemiology","published":"2026-05-28","design":"human_cross_sectional","finding":"mixed","summary":"Personal monitors were deployed at a furniture manufacturing facility to measure occupational exposure to formaldehyde, particulate matter, and noise during a full work shift.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"full_text","verified":false}],"model":"gemini-3.8-flash","run":{"aiCalls":35,"cachedPapers":1,"offTopic":21,"inputTokens":22334,"outputTokens":4300}}