{"v":1,"ledgerId":"glyphosate","generatedAt":"2026-11-05T21:03:31.781Z","query":"(TITLE:(\"Glyphosate\" OR \"GLYPHOSATE\" OR \"N-(PHOSPHONOMETHYL)GLYCINE\" OR \"POEA TALLOWAMINE\" OR \"1071-83-6\") OR ABSTRACT:(\"Glyphosate\" OR \"GLYPHOSATE\" OR \"N-(PHOSPHONOMETHYL)GLYCINE\" OR \"POEA TALLOWAMINE\" OR \"1071-83-6\")) AND (TOXICITY OR EXPOSURE OR \"ENDOCRINE\" OR \"REPRODUCTIVE\" OR CARCINOGEN* OR \"BIOMONITORING\" OR \"SYSTEMATIC REVIEW\") AND SRC:MED AND LANG:eng","totalPapers":3447,"lastYearPapers":367,"analysed":32,"byFunding":{"independent":15,"industry":1,"mixed":0,"none_declared":0,"unclear":16},"byDesign":{"human":3,"animal":12,"in_vitro":4,"review":1,"other":12},"byFinding":{"concern":21,"no_effect":9,"mixed":2},"gap":{"independent":{"concern":11,"total":15},"industry":{"concern":0,"total":1}},"fundingSources":{"full_text":8,"grant_metadata":14,"abstract":0,"none":10},"newestPublished":"2026-10-30","papers":[{"id":"pmid:42962638","pmid":"42962638","pmcid":"","doi":"10.1016/j.jhazmat.2026.144060","title":"Glyphosate exposure alters the faecal corticosterone metabolite profile in a lizard: Validation and application of an enzyme immunoassay in Podarcis bocagei.","journal":"Journal of hazardous materials","published":"2026-10-30","design":"animal","finding":"concern","summary":"Glyphosate exposure in Podarcis bocagei wall lizards moderately increased faecal corticosterone metabolite levels and altered their mass-dependent metabolite profile.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42954952","pmid":"42954952","pmcid":"","doi":"10.1080/1059924x.2026.2750269","title":"Environmental Toxicovigilance Among Rural Women in Agricultural Regions of Southern Brazil: A Community-Based Educational Intervention Supported by Human Biomonitoring.","journal":"Journal of agromedicine","published":"2026-10-29","design":"other","finding":"no_effect","summary":"An educational intervention among rural women farmers in Brazil was associated with significantly reduced urinary glyphosate concentrations.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42950995","pmid":"42950995","pmcid":"","doi":"10.1016/j.cbpc.2026.110731","title":"The combined toxicity of polystyrene microplastics and glyphosate on Daphnia magna: Physiological and behavioral responses.","journal":"Comparative biochemistry and physiology. Toxicology & pharmacology : CBP","published":"2026-10-28","design":"animal","finding":"concern","summary":"Exposure of Daphnia magna to glyphosate and microplastics altered heart rate and swimming behavior, induced oxidative stress, exacerbated apoptosis, and caused intestinal damage.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42946284","pmid":"42946284","pmcid":"","doi":"10.1016/j.etap.2026.105213","title":"Recombinogenic potency analysis of a commercial glyphosate-based herbicide formulation on the soil filamentous fungus Aspergillus nidulans.","journal":"Environmental toxicology and pharmacology","published":"2026-10-27","design":"in_vitro","finding":"concern","summary":"Exposure to a commercial glyphosate-based herbicide formulation increased mitotic segregation frequency via crossing-over or gene conversion in metabolically active Aspergillus nidulans.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42931972","pmid":"42931972","pmcid":"","doi":"10.1007/s00244-026-01228-y","title":"Does Exposure to Glyphosate-Based Herbicide Affect the Aerobic Metabolism, Oxidative Stress and Fatty Acid Profile of Pacú (Piaractus mesopotamicus)?","journal":"Archives of environmental contamination and toxicology","published":"2026-10-26","design":"animal","finding":"mixed","summary":"Exposure to Roundup Control Max increased brain oxidative stress and altered metabolic delta in pacú, while basal metabolism and lipid profiles showed no significant changes.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Ministerio de\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42962382","pmid":"42962382","pmcid":"","doi":"10.1016/j.aquatox.2026.108064","title":"Planktonic community rescue under herbicide pollution: the driving factors and ecological consequences.","journal":"Aquatic toxicology (Amsterdam, Netherlands)","published":"2026-10-26","design":"other","finding":"concern","summary":"Aquatic planktonic communities exposed to herbicide experienced community rescue accompanied by reduced taxonomic diversity, lower primary productivity, and simplified ecological interaction networks.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42909559","pmid":"42909559","pmcid":"PMC13694482","doi":"10.1007/s10646-026-03179-5","title":"Context-dependent sublethal hazard of glyphosate to non-target predators revealed by functional response analysis.","journal":"Ecotoxicology (London, England)","published":"2026-10-23","design":"animal","finding":"concern","summary":"Exposure to a glyphosate-based herbicide significantly reduced predation rates in adult female Pardosa wolf spiders, an effect modulated by antibiotic pre-treatment.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Ministry of\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42913927","pmid":"42913927","pmcid":"","doi":"10.1016/j.etap.2026.105205","title":"Enzymatic biomarkers reveal species-specific sensitivity of bees to imidacloprid, glyphosate, and combined exposure.","journal":"Environmental toxicology and pharmacology","published":"2026-10-22","design":"animal","finding":"concern","summary":"Sublethal exposure to glyphosate, imidacloprid, and their mixture induced species-specific alterations in enzymatic biomarkers in Apis mellifera and Melipona quadrifasciata bees.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Research Foundation\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42895966","pmid":"42895966","pmcid":"","doi":"10.1002/ps.71408","title":"Glyphosate residues in Chinese tea: a national survey, contamination pathway and risk assessment.","journal":"Pest management science","published":"2026-10-19","design":"other","finding":"no_effect","summary":"Glyphosate was detected in 27.4% of 1,013 Chinese tea samples, but estimated consumer exposure and hazard quotients were several orders of magnitude below levels of concern.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42943140","pmid":"42943140","pmcid":"PMC13709102","doi":"10.3390/plants15203186","title":"Characterization of Low-Level Glyphosate Tolerance in an <i>Abutilon theophrasti</i> Population from a Soybean Field.","journal":"Plants (Basel, Switzerland)","published":"2026-10-17","design":"other","finding":"no_effect","summary":"An Abutilon theophrasti population exhibited low-level glyphosate tolerance associated with higher constitutive EPSPS activity and in vitro inhibition IC50 without changes in absorption or gene expression.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"full_text","verified":false},{"id":"pmid:42943611","pmid":"42943611","pmcid":"PMC13707483","doi":"10.3390/microorganisms14102371","title":"Steppe-Derived Glyphosate-Tolerant <i>Pseudomonas</i> sp. ADL-13 and <i>Paenibacillus</i> sp. ZHS-9 Strains with Plant Growth-Promoting Traits and Broad Abiotic Stress Tolerance.","journal":"Microorganisms","published":"2026-10-16","design":"in_vitro","finding":"no_effect","summary":"Pseudomonas sp. ADL-13 and Paenibacillus sp. ZHS-9 tolerated in vitro glyphosate exposure up to 2.0 g/L and exhibited plant growth-promoting traits in wheat seedlings.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Ministry of\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42878745","pmid":"42878745","pmcid":"","doi":"10.1039/d6em00677a","title":"Water quality assessment in two agricultural streams in the pampas region, Argentina: an integrated landscape, physicochemical, chemical, and ecotoxicological approach.","journal":"Environmental science. Processes & impacts","published":"2026-10-15","design":"animal","finding":"concern","summary":"Stream water samples containing glyphosate, AMPA, and other agrochemicals induced significant larval mortality, oxidative stress alterations, and cholinesterase inhibition in Rhinella arenarum larvae.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42867269","pmid":"42867269","pmcid":"","doi":"10.1080/19440049.2026.2741930","title":"Dietary exposure to five highly polar pesticides of the Hong Kong population through a total diet study.","journal":"Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment","published":"2026-10-13","design":"other","finding":"no_effect","summary":"Dietary exposure assessment in Hong Kong found exposure to five polar pesticides, including glyphosate, was unlikely to pose a significant health risk to adult and younger populations.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42853511","pmid":"42853511","pmcid":"","doi":"10.1007/s10661-026-15973-z","title":"Environmental occurrence, spatial distribution, and probabilistic dietary risk assessment of cypermethrin and glyphosate residues in agricultural ecosystems of southwestern Nigeria.","journal":"Environmental monitoring and assessment","published":"2026-10-09","design":"other","finding":"no_effect","summary":"Glyphosate predominated in soil and sediment in southwestern Nigeria, but dietary risk assessments showed acceptable exposure levels below hazard thresholds for both adults and children.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42838538","pmid":"42838538","pmcid":"","doi":"10.1002/jat.70475","title":"Effects of Glyphosate and Glyphosate-Based Herbicides on the Mammalian Gut Microbiome: A Critical Review.","journal":"Journal of applied toxicology : JAT","published":"2026-10-06","design":"other","finding":"concern","summary":"A critical review found that glyphosate and glyphosate-based herbicides can perturb the rodent gut microbiome, with formulated products frequently showing greater disruption than the active ingredient alone.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42815867","pmid":"42815867","pmcid":"","doi":"10.1016/j.fsi.2026.111752","title":"Environmentally relevant glyphosate exposure increases susceptibility to tilapia lake virus through disruption of antiviral immunity in Nile tilapia.","journal":"Fish & shellfish immunology","published":"2026-09-30","design":"animal","finding":"concern","summary":"Oral exposure to glyphosate disrupted antiviral immunity and increased susceptibility to tilapia lake virus infection in Nile tilapia.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42849153","pmid":"42849153","pmcid":"","doi":"10.1016/j.aquatox.2026.108044","title":"Roundup® induces oxidative stress in zebrafish liver cell line (ZF-L): Role of the Nrf pathway and uncoupling proteins.","journal":"Aquatic toxicology (Amsterdam, Netherlands)","published":"2026-09-30","design":"in_vitro","finding":"concern","summary":"Exposure of zebrafish liver cells to Roundup increased ROS levels, altered Nrf2 and ucp3 gene expression, and induced persistent oxidative DNA damage at the highest tested concentration.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Conselho Nacional de Desenvolvimento\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42802543","pmid":"42802543","pmcid":"","doi":"10.1080/01480545.2026.2726183","title":"Subacute oral glyphosate induces dose-dependent renal injury in male mice (<i>Mus musculus</i>).","journal":"Drug and chemical toxicology","published":"2026-09-27","design":"animal","finding":"concern","summary":"Subacute oral administration of technical-grade glyphosate at 50 and 100 mg/kg/day caused dose-dependent renal injury, oxidative stress, and histopathological lesions in male mice.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42767439","pmid":"42767439","pmcid":"","doi":"10.1016/j.toxlet.2026.113205","title":"Glyphosate alters the neurochemical phenotype of enteric neurons and modulates cytokine levels in the porcine ileum.","journal":"Toxicology letters","published":"2026-09-21","design":"animal","finding":"concern","summary":"Glyphosate exposure at doses matching safety thresholds altered enteric neuron phenotypes and elevated IL-1β and IL-6 levels in the porcine ileum.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42784947","pmid":"42784947","pmcid":"","doi":"10.1016/j.jhazmat.2026.143566","title":"Glyphosate exposure and epigenetic-environmental interactions in ASD: The role of circTiam1.","journal":"Journal of hazardous materials","published":"2026-09-10","design":"animal","finding":"concern","summary":"Maternal exposure to glyphosate-based herbicide induced ASD-like behaviors and microglial dysfunction in mice via a circTiam1-mediated pathway.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42722096","pmid":"42722096","pmcid":"","doi":"10.1016/j.envres.2026.125644","title":"Pesticide exposure during pregnancy and the risk of adverse maternal and fetal outcomes: a systematic review.","journal":"Environmental research","published":"2026-09-10","design":"systematic_review","finding":"concern","summary":"A systematic review found maternal exposure to pesticides during pregnancy, including glyphosate, was associated with shortened gestational duration and increased risk of preterm birth.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Fundação para a Ciência\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42660472","pmid":"42660472","pmcid":"","doi":"10.1016/j.bbagen.2026.130991","title":"Glyphosate uptake pathway across the outer membrane of Pseudomonas aeruginosa.","journal":"Biochimica et biophysica acta. General subjects","published":"2026-08-27","design":"in_vitro","finding":"no_effect","summary":"Electrophysiology and molecular dynamics simulations demonstrate that glyphosate permeates across the outer membrane of Pseudomonas aeruginosa through OprO and OprP channels.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"DFG\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42648508","pmid":"42648508","pmcid":"","doi":"10.1016/j.fsi.2026.111682","title":"Glyphosate induces intestinal inflammatory injury associated with mitochondrial-lysosomal dysfunction, cGAS-STING activation, and pyroptosis-related responses in common carp (Cyprinus carpio L.).","journal":"Fish & shellfish immunology","published":"2026-08-26","design":"animal","finding":"concern","summary":"Glyphosate exposure caused intestinal inflammatory injury, ROS overproduction, mitochondrial-lysosomal dysfunction, and pyroptosis in common carp and EPC cells.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"National Natural Science Foundation of China\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42639821","pmid":"42639821","pmcid":"","doi":"10.1080/01480545.2026.2714874","title":"Integrated assessment of pesticides, inorganic ions, and health risks in drinking water from Missal, a rural agricultural municipality in Southern Brazil.","journal":"Drug and chemical toxicology","published":"2026-08-25","design":"other","finding":"concern","summary":"Glyphosate was detected in 53% of drinking water samples in a Brazilian agricultural municipality, where water samples showed cytotoxicity and genotoxicity in Allium cepa assays.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"CAPES\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42448271","pmid":"42448271","pmcid":"PMC13564233","doi":"10.1016/j.envpol.2026.128775","title":"Associations of glyphosate exposure in pregnancy with preterm birth: a longitudinal birth cohort study.","journal":"Environmental pollution (Barking, Essex : 1987)","published":"2026-07-14","design":"human_cohort","finding":"concern","summary":"Urinary glyphosate concentrations at 18 to 25 weeks of pregnancy were associated with increased odds of preterm birth and spontaneous preterm birth in a prospective cohort study.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"NIEHS\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42297896","pmid":"42297896","pmcid":"PMC13727658","doi":"10.1038/s41370-026-00902-6","title":"Glyphosate exposure and hormonal disruption in pregnancy: evidence from a birth cohort in Puerto Rico.","journal":"Journal of exposure science & environmental epidemiology","published":"2026-06-15","design":"human_cohort","finding":"concern","summary":"Urinary glyphosate and AMPA concentrations were associated with reduced estriol and alterations in thyroid and stress hormones among pregnant women in a Puerto Rico birth cohort.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"National Institute of Environmental Health\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42036107","pmid":"42036107","pmcid":"","doi":"10.1002/jat.70222","title":"Review of Organophosphorus Herbicide: Distribution of Residues, Toxicity Effects, Mechanisms, and Developing Trends Studies.","journal":"Journal of applied toxicology : JAT","published":"2026-04-26","design":"other","finding":"concern","summary":"A review of organophosphorus herbicides including glyphosate summarizes environmental residue levels and reports associations with neurotoxicity, genotoxicity, and metabolic toxicity in epidemiological investigations.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"National Natural Science Foundation of China\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:41804601","pmid":"41804601","pmcid":"PMC12977275","doi":"10.1080/21645698.2026.2627101","title":"Engineering glyphosate tolerance in sugarcane through overexpression of a mutated version of its native <i>EPSPS</i> gene.","journal":"GM crops & food","published":"2026-03-10","design":"other","finding":"no_effect","summary":"Transgenic sugarcane overexpressing a mutated endogenous ScEPSPS gene demonstrated tolerance to glyphosate without compromising overall phenotype, growth, or development under greenhouse conditions.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Coordenação de Aperfeiçoamento\""],"fundingSource":"full_text","verified":false},{"id":"pmid:41797357","pmid":"41797357","pmcid":"PMC13628424","doi":"10.1002/jat.70132","title":"Health Biomarkers of Pesticide Exposure in Rural Populations of Santa Fe, Argentina: Oxidative Stress and Genotoxicity.","journal":"Journal of applied toxicology : JAT","published":"2026-03-08","design":"human_cross_sectional","finding":"concern","summary":"Rural participants exposed to environmental pesticides, including glyphosate and AMPA, exhibited higher blood pesticide detection rates alongside increased oxidative stress and genotoxic biomarkers compared to controls.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Universidad\""],"fundingSource":"full_text","verified":false},{"id":"pmid:41760578","pmid":"41760578","pmcid":"","doi":"10.1002/jat.70142","title":"Ecotoxicological Assessment of a Glyphosate-Based Commercial Formulation and a Novel Experimental Formulation by Standardized Amphibian Bioassays.","journal":"Journal of applied toxicology : JAT","published":"2026-02-27","design":"animal","finding":"concern","summary":"A commercial glyphosate formulation showed significantly higher lethality, morphological abnormalities, neurotoxicity, and genotoxicity in Rhinella arenarum embryos and larvae compared to an experimental formulation.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:41503868","pmid":"41503868","pmcid":"PMC12785226","doi":"10.1080/21645698.2025.2603719","title":"Breeding of glyphosate-tolerant genetically modified rice BriA15-38.","journal":"GM crops & food","published":"2026-01-07","design":"other","finding":"no_effect","summary":"Genetically modified rice expressing the aroA A1501 gene demonstrated tolerance to glyphosate concentrations up to 8000 ppm while maintaining normal metabolic activity.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"full_text","verified":false},{"id":"pmid:41411675","pmid":"41411675","pmcid":"PMC12721089","doi":"10.1080/21645698.2025.2594217","title":"Glyphosate use in agricultural production: it's contribution to global carbon dioxide emissions.","journal":"GM crops & food","published":"2025-12-18","design":"other","finding":"mixed","summary":"Glyphosate manufacture, distribution, and use generate 9.76 billion kg CO2e annually, but its facilitation of conservation tillage provides an estimated net annual reduction of 54.94 billion kg CO2e.","funding":"industry","conflictOfInterest":false,"fundingEvidence":["industry: \"Bayer\""],"fundingSource":"full_text","verified":false}],"model":"gemini-3.8-flash","run":{"aiCalls":40,"cachedPapers":0,"offTopic":8,"inputTokens":25861,"outputTokens":5466}}