{"v":1,"ledgerId":"nano-silver","generatedAt":"2026-11-05T22:16:59.113Z","query":"(TITLE:(\"Colloidal Nano-Silver\" OR \"COLLOIDAL SILVER\" OR \"CI 77820 (NANO)\" OR \"SILVER CITRATE\" OR \"7440-22-4\") OR ABSTRACT:(\"Colloidal Nano-Silver\" OR \"COLLOIDAL SILVER\" OR \"CI 77820 (NANO)\" OR \"SILVER CITRATE\" OR \"7440-22-4\")) AND (TOXICITY OR EXPOSURE OR \"ENDOCRINE\" OR \"REPRODUCTIVE\" OR CARCINOGEN* OR \"BIOMONITORING\" OR \"SYSTEMATIC REVIEW\") AND SRC:MED AND LANG:eng","totalPapers":185,"lastYearPapers":11,"analysed":25,"byFunding":{"independent":13,"industry":0,"mixed":0,"none_declared":5,"unclear":7},"byDesign":{"human":1,"animal":2,"in_vitro":15,"review":0,"other":7},"byFinding":{"concern":10,"no_effect":13,"mixed":2},"gap":{"independent":{"concern":6,"total":13},"industry":{"concern":0,"total":0}},"fundingSources":{"full_text":17,"grant_metadata":4,"abstract":0,"none":4},"newestPublished":"2026-09-26","papers":[{"id":"pmid:42819456","pmid":"42819456","pmcid":"PMC13625844","doi":"10.2147/ijn.s583827","title":"A Preliminary in-vitro Evaluation of Serum Capped Colloidal Silver Nanoparticles on Liver Cancer towards Development of Safe Personalized Nanomedicine.","journal":"International journal of nanomedicine","published":"2026-09-26","design":"animal","finding":"mixed","summary":"Serum-capped silver nanoparticles demonstrated lower toxicity in mice and normal cells compared to PVA-capped nanoparticles, while exhibiting cytotoxicity against liver cancer cells.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"full_text","verified":false},{"id":"pmid:42092482","pmid":"42092482","pmcid":"","doi":"10.1016/j.ajic.2026.04.022","title":"Effects of chlorhexidine gluconate and alternative cleansers in pediatric skin cells in vitro: Are there less toxic alternatives?","journal":"American journal of infection control","published":"2026-05-04","design":"in_vitro","finding":"no_effect","summary":"In pediatric skin cells in vitro, colloidal silver foam had the least effect on proliferation and did not significantly affect migration compared to chlorhexidine gluconate.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:41997985","pmid":"41997985","pmcid":"PMC13246749","doi":"10.1038/s41598-026-45070-7","title":"Network ontology transcript annotation identifies genetic signals underlying sex determination.","journal":"Scientific reports","published":"2026-04-17","design":"other","finding":"mixed","summary":"Transcriptomic analysis of cannabis treated with colloidal silver identified candidate sex-determination genes and indicated silver ion treatment perturbs phytohormone signal transduction via metal ion imbalance.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"NIH\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:41402371","pmid":"41402371","pmcid":"PMC12708763","doi":"10.1038/s41598-025-28841-6","title":"Research on the impact of ecological additives on selected parameters and the microbiological distribution of marine engine oil.","journal":"Scientific reports","published":"2025-12-16","design":"other","finding":"no_effect","summary":"Addition of colloidal nanosilver to marine engine oil affected physical properties like temperature and water content while decreasing the growth of bacteria and fungi.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:41345501","pmid":"41345501","pmcid":"PMC12779990","doi":"10.1038/s41598-025-30332-7","title":"A comparative evaluation of green colloidal silver variants for enhanced stability and bioactivity.","journal":"Scientific reports","published":"2025-12-05","design":"in_vitro","finding":"no_effect","summary":"Green-synthesized colloidal silver variants demonstrated stability under stress conditions, along with antioxidant activity and antimicrobial efficacy against E. coli and Listeria.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"full_text","verified":false},{"id":"pmid:41373847","pmid":"41373847","pmcid":"PMC12692570","doi":"10.3390/ijms262311703","title":"Genotoxicity Assessment of Silver Nanoparticles Produced via HVAD: Examination of Sister Chromatid Exchanges in <i>Chinchilla lanigera</i> Blood Lymphocytes In Vitro.","journal":"International journal of molecular sciences","published":"2025-12-03","design":"in_vitro","finding":"concern","summary":"In vitro exposure of Chinchilla lanigera blood lymphocytes to silver nanoparticles increased sister chromatid exchanges, indicating genotoxicity, with citrate-stabilized nanoparticles causing the highest damage.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University\""],"fundingSource":"full_text","verified":false},{"id":"pmid:41304544","pmid":"41304544","pmcid":"PMC12656528","doi":"10.3390/toxics13110992","title":"Potential Toxicological Risk Associated with the Oral Use of Colloidal Silver Dietary Supplements.","journal":"Toxics","published":"2025-11-18","design":"other","finding":"concern","summary":"Physicochemical analysis and theoretical intake calculations of commercial colloidal silver supplements indicated intake levels that could exceed the EPA oral reference dose.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Ministry of\""],"fundingSource":"full_text","verified":false},{"id":"pmid:41012525","pmid":"41012525","pmcid":"PMC12473813","doi":"10.3390/pharmaceutics17091189","title":"Sprayable Hybrid Gel with Cannabidiol, Hyaluronic Acid, and Colloidal Silver: A Multifunctional Approach for Skin Lesion Therapy.","journal":"Pharmaceutics","published":"2025-09-12","design":"in_vitro","finding":"no_effect","summary":"A sprayable hyaluronic acid hydrogel containing cannabidiol and colloidal silver showed antimicrobial activity and maintained over 70% cell viability in normal human dermal fibroblasts.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University of Medicine and Pharmacy of Craiova, Romania European Research Executive Agency HORIZON-MSCA-2022-SE-01-01 The article processing charges were funded by the University of Medicine and Pharmacy of Craiova, Romania. This work was supported by a grant\""],"fundingSource":"full_text","verified":false},{"id":"pmid:41124576","pmid":"41124576","pmcid":"","doi":"10.1080/17435390.2025.2573968","title":"Silver ion toxicity in commercial colloidal silver: molecular insights from high-content imaging in Huh-7 cells.","journal":"Nanotoxicology","published":"2025-09-01","design":"in_vitro","finding":"concern","summary":"Commercial colloidal silver formulations reduced viability and caused cellular alterations in human Huh-7 cells, with cytotoxicity driven primarily by the silver ion-enriched supernatant.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Conselho Nacional de Desenvolvimento\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:40284788","pmid":"40284788","pmcid":"PMC12029289","doi":"10.3390/microorganisms13040952","title":"Silver Nanoparticles and Antibiotics: A Promising Synergistic Approach to Multidrug-Resistant Infections.","journal":"Microorganisms","published":"2025-04-21","design":"other","finding":"no_effect","summary":"This review discusses the synergistic antibacterial effects of silver nanoparticles combined with antibiotics to combat multidrug-resistant infections via controlled silver ion release.","funding":"independent","conflictOfInterest":true,"fundingEvidence":["public: \"European Union\"","COI: \"employed by\""],"fundingSource":"full_text","verified":false},{"id":"pmid:40284467","pmid":"40284467","pmcid":"PMC12030705","doi":"10.3390/pharmaceutics17040472","title":"Topical Administration of Vitamin D2 Combined with Colloidal Silver Nanoparticles Promotes Wound Repair and Protection Against Skin Irritation and UVB Irradiation in 3D Reconstructed Human Skin Models.","journal":"Pharmaceutics","published":"2025-04-04","design":"in_vitro","finding":"no_effect","summary":"Topical cream containing vitamin D2 and silver nanoparticles improved wound healing and protected reconstructed human skin models from SDS irritation and UVB irradiation damage.","funding":"none_declared","conflictOfInterest":false,"fundingEvidence":["none: \"This research received no\""],"fundingSource":"full_text","verified":false},{"id":"pmid:39858937","pmid":"39858937","pmcid":"PMC11767636","doi":"10.3390/microorganisms13010169","title":"Exploring Metal Ions as Potential Antimicrobial Agents to Combat Future Drug Resistance in Mycoplasma bovis.","journal":"Microorganisms","published":"2025-01-15","design":"in_vitro","finding":"no_effect","summary":"Colloidal silver demonstrated antimicrobial activity against clinical Mycoplasma bovis isolates, inhibiting 81.25% of isolates at 1.5 mg/L in vitro.","funding":"none_declared","conflictOfInterest":false,"fundingEvidence":["none: \"This research received no\""],"fundingSource":"full_text","verified":false},{"id":"pmid:39684401","pmid":"39684401","pmcid":"PMC11641675","doi":"10.3390/ijms252312691","title":"Cytokinesis-Blocking Micronucleus Assay for Assessing Nuclear Chromatin Integrity Abnormalities in Dog's Somatic Cells After Exposure to HVAD-Produced Silver Nanoparticles.","journal":"International journal of molecular sciences","published":"2024-11-26","design":"in_vitro","finding":"concern","summary":"In vitro exposure of dog peripheral blood cells to colloidal silver nanoparticles increased micronuclei, nuclear buds, and nucleoplasmic bridges without producing cytotoxic effects.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University\""],"fundingSource":"full_text","verified":false},{"id":"pmid:39065720","pmid":"39065720","pmcid":"PMC11279972","doi":"10.3390/ph17070869","title":"Synthesis of Silver Nanoparticles Using Extracts from Different Parts of the Paullinia cupana Kunth Plant: Characterization and In Vitro Antimicrobial Activity.","journal":"Pharmaceuticals (Basel, Switzerland)","published":"2024-07-02","design":"in_vitro","finding":"no_effect","summary":"Silver nanoparticles synthesized using Paullinia cupana leaf and flower extracts showed stable colloidal properties and in vitro antimicrobial activity against pathogenic microorganisms.","funding":"independent","conflictOfInterest":true,"fundingEvidence":["public: \"CNPq\"","COI: \"employed by\""],"fundingSource":"full_text","verified":false},{"id":"pmid:38929669","pmid":"38929669","pmcid":"PMC11204856","doi":"10.3390/life14060687","title":"Optimizing Allelopathy Screening Bioassays by Using Nano Silver.","journal":"Life (Basel, Switzerland)","published":"2024-05-27","design":"in_vitro","finding":"concern","summary":"Higher concentrations of colloidal nano silver inhibited seed germination and early growth of Lactuca sativa, whereas lower concentrations had little to no stimulatory effect.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"European Union\""],"fundingSource":"full_text","verified":false},{"id":"pmid:38696892","pmid":"38696892","pmcid":"PMC11078632","doi":"10.1016/j.bjorl.2024.101436","title":"Non-antibiotic antimicrobial agents for chronic rhinosinusitis: a narrative review.","journal":"Brazilian journal of otorhinolaryngology","published":"2024-04-26","design":"other","finding":"no_effect","summary":"A narrative review found that colloidal silver nasal irrigation showed limited efficacy in reducing chronic rhinosinusitis symptoms or endoscopic scores in adults.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Coordenação de Aperfeiçoamento\""],"fundingSource":"full_text","verified":false},{"id":"pmid:38576574","pmid":"38576574","pmcid":"PMC10990857","doi":"10.1016/j.heliyon.2024.e28430","title":"Nanometals incorporation into active and biodegradable chitosan films.","journal":"Heliyon","published":"2024-03-26","design":"in_vitro","finding":"no_effect","summary":"Incorporation of colloidal silver nanoparticles into biodegradable chitosan films enhanced antioxidant capacity and antimicrobial activity.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:39036009","pmid":"39036009","pmcid":"PMC11257724","doi":"10.47717/turkjsurg.2024.6168","title":"Effect of silver colloid dressing over conventional dressings in diabetic foot ulcer: A prospective study.","journal":"Turkish journal of surgery","published":"2024-03-23","design":"human_rct","finding":"no_effect","summary":"Silver colloid dressings significantly accelerated healing and reduced ulcer area compared to conventional saline dressings in patients with diabetic foot ulcers.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:37872532","pmid":"37872532","pmcid":"PMC10591374","doi":"10.1186/s12866-023-03062-x","title":"Sub-lethal concentration of a colloidal nanosilver formulation (Silversol®) triggers dysregulation of iron homeostasis and nitrogen metabolism in multidrug resistant Pseudomonas aeruginosa.","journal":"BMC microbiology","published":"2023-10-23","design":"in_vitro","finding":"concern","summary":"Sub-lethal concentrations of colloidal nanosilver formulation Silversol dysregulated nitrogen metabolism, iron homeostasis, and quorum-sensing regulated traits in multidrug-resistant Pseudomonas aeruginosa.","funding":"none_declared","conflictOfInterest":false,"fundingEvidence":["none: \"This research received no\""],"fundingSource":"full_text","verified":false},{"id":"pmid:37767535","pmid":"37767535","pmcid":"PMC10520504","doi":"10.1016/j.toxrep.2023.09.012","title":"Colloidal silver ingestion and severe anemia - A case report.","journal":"Toxicology reports","published":"2023-09-20","design":"other","finding":"concern","summary":"Daily colloidal silver ingestion in a woman was associated with severe anemia, abnormal liver function, incipient heart failure, and elevated whole-blood silver concentrations.","funding":"none_declared","conflictOfInterest":false,"fundingEvidence":["none: \"did not receive any specific grant\""],"fundingSource":"full_text","verified":false},{"id":"pmid:37661312","pmid":"37661312","pmcid":"PMC11469222","doi":"10.1002/adhm.202302084","title":"The Origin of the Intracellular Silver in Bacteria: A Comprehensive Study using Targeting Gold-Silver Alloy Nanoparticles.","journal":"Advanced healthcare materials","published":"2023-09-17","design":"in_vitro","finding":"concern","summary":"Exposure of Staphylococcus aureus to colloidal silver-gold alloy nanoparticles resulted in the intracellular formation of pure silver nanoparticles smaller than 10 nm via a release-penetration-reduction mechanism.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Deutsche Forschungsgemeinschaft\""],"fundingSource":"full_text","verified":false},{"id":"pmid:37552252","pmid":"37552252","pmcid":"PMC10484803","doi":"10.1007/s00253-023-12710-1","title":"Antibacterial efficiency over time and barrier properties of wood coatings with colloidal silver.","journal":"Applied microbiology and biotechnology","published":"2023-08-08","design":"in_vitro","finding":"no_effect","summary":"Wood coatings with colloidal silver showed sustained antibacterial activity against E. coli and S. aureus and water resistance, but experienced oxidation when exposed to acidic environments.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"full_text","verified":false},{"id":"pmid:37400872","pmid":"37400872","pmcid":"PMC10318827","doi":"10.1186/s13104-023-06392-1","title":"Potent anthelmintic activity of a colloidal nano-silver formulation (Silversol®) against the model worm Caenorhabditis elegans.","journal":"BMC research notes","published":"2023-07-03","design":"animal","finding":"concern","summary":"A colloidal nano-silver formulation exhibited anthelmintic activity against Caenorhabditis elegans, causing cuticle damage and complete mortality at concentrations of 2 ppm or higher.","funding":"none_declared","conflictOfInterest":false,"fundingEvidence":["none: \"This research received no\""],"fundingSource":"full_text","verified":false},{"id":"pmid:37360209","pmid":"37360209","pmcid":"PMC10288451","doi":"10.1177/00185787231151862","title":"Seizures Following Self-Medication With Colloidal Silver: A Case Report.","journal":"Hospital pharmacy","published":"2023-03-17","design":"other","finding":"concern","summary":"A case report describes a 70-year-old man who experienced seizures following self-medication with colloidal silver.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:36729280","pmid":"36729280","pmcid":"","doi":"10.1007/s10534-023-00494-w","title":"Colloidal silver against macrophage infections and biofilms of atypical mycobacteria.","journal":"Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine","published":"2023-02-02","design":"in_vitro","finding":"no_effect","summary":"Green synthesized colloidal silver inhibited atypical mycobacteria and reduced macrophage infection without exhibiting cytotoxicity in human keratinocytes and fibroblasts at concentrations under 3 ppm.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false}],"model":"gemini-3.8-flash","run":{"aiCalls":39,"cachedPapers":0,"offTopic":14,"inputTokens":25348,"outputTokens":4903}}