{"v":1,"ledgerId":"p-phenylenediamine","generatedAt":"2026-11-05T22:02:15.517Z","query":"(TITLE:(\"p-Phenylenediamine\" OR \"P-PHENYLENEDIAMINE\" OR \"RESORCINOL\" OR \"TOLUENE-2,5-DIAMINE SULFATE\" OR \"106-50-3\") OR ABSTRACT:(\"p-Phenylenediamine\" OR \"P-PHENYLENEDIAMINE\" OR \"RESORCINOL\" OR \"TOLUENE-2,5-DIAMINE SULFATE\" OR \"106-50-3\")) AND (TOXICITY OR EXPOSURE OR \"ENDOCRINE\" OR \"REPRODUCTIVE\" OR CARCINOGEN* OR \"BIOMONITORING\" OR \"SYSTEMATIC REVIEW\") AND SRC:MED AND LANG:eng","totalPapers":1330,"lastYearPapers":192,"analysed":4,"byFunding":{"independent":1,"industry":0,"mixed":0,"none_declared":1,"unclear":2},"byDesign":{"human":1,"animal":0,"in_vitro":1,"review":0,"other":2},"byFinding":{"concern":2,"no_effect":1,"mixed":1},"gap":{"independent":{"concern":0,"total":1},"industry":{"concern":0,"total":0}},"fundingSources":{"full_text":3,"grant_metadata":1,"abstract":0,"none":0},"newestPublished":"2026-10-14","papers":[{"id":"pmid:42941879","pmid":"42941879","pmcid":"PMC13705402","doi":"10.3390/ijms27209109","title":"Restoration of PPD-Induced Injury in iHDPCs via the OS-Mitochondrial Apoptosis Pathway: Screening and Validation of Natural Compounds.","journal":"International journal of molecular sciences","published":"2026-10-14","design":"in_vitro","finding":"concern","summary":"Curcumin, resveratrol, and astragaloside IV alleviated p-phenylenediamine-induced cellular damage and markers of mitochondrial apoptosis in human immortalized dermal papilla cells.","funding":"none_declared","conflictOfInterest":false,"fundingEvidence":["none: \"This research received no\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42843247","pmid":"42843247","pmcid":"","doi":"10.1016/j.jhazmat.2026.143811","title":"Emerging contaminants in microalgae-based sustainable foods: occurrence patterns and dietary risk implications.","journal":"Journal of hazardous materials","published":"2026-10-04","design":"other","finding":"no_effect","summary":"Analysis of 77 microalgae-based food samples showed widespread detection of butylparaben and other contaminants, but dietary risks from parabens were limited with hazard index values below 1.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"National Key Research and Development Program\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42802511","pmid":"42802511","pmcid":"PMC13732281","doi":"10.1111/cod.70253","title":"Occupational Allergic Contact Dermatitis due to Rubber Additives in Tunisia: A 27-Year Retrospective Study of Clinical and Occupational Characteristics.","journal":"Contact dermatitis","published":"2026-09-27","design":"human_cohort","finding":"concern","summary":"In a Tunisian retrospective study of occupational allergic contact dermatitis from rubber additives, 14% of patients showed sensitization to p-phenylenediamine derivatives.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"full_text","verified":false},{"id":"pmid:42709654","pmid":"42709654","pmcid":"PMC13685046","doi":"10.1159/drm/ackag017","title":"Resorcinol in Dermatology: Reassessing a Legacy Topical Therapy for Contemporary Clinical Use.","journal":"Dermatology (Basel, Switzerland)","published":"2026-09-08","design":"other","finding":"mixed","summary":"Topical resorcinol demonstrates therapeutic properties for specific dermatologic conditions, while safety concerns such as thyroid toxicity primarily stem from prolonged high-dose use on compromised skin.","funding":"unclear","conflictOfInterest":true,"fundingEvidence":["COI: \"stock\""],"fundingSource":"full_text","verified":false}],"model":"gemini-3.8-flash","run":{"aiCalls":38,"cachedPapers":2,"offTopic":36,"inputTokens":26292,"outputTokens":5003}}