{"v":1,"ledgerId":"pfas","generatedAt":"2026-11-05T20:43:10.014Z","query":"(TITLE:(\"PFAS / PTFE\" OR \"PTFE\" OR \"POLYTEFLUOROETHYLENE\" OR \"PERFLUORONONYL DIMETHICONE\" OR \"335-67-1\") OR ABSTRACT:(\"PFAS / PTFE\" OR \"PTFE\" OR \"POLYTEFLUOROETHYLENE\" OR \"PERFLUORONONYL DIMETHICONE\" OR \"335-67-1\")) AND (TOXICITY OR EXPOSURE OR \"ENDOCRINE\" OR \"REPRODUCTIVE\" OR CARCINOGEN* OR \"BIOMONITORING\" OR \"SYSTEMATIC REVIEW\") AND SRC:MED AND LANG:eng","totalPapers":974,"lastYearPapers":140,"analysed":10,"byFunding":{"independent":5,"industry":0,"mixed":0,"none_declared":0,"unclear":5},"byDesign":{"human":0,"animal":4,"in_vitro":2,"review":0,"other":4},"byFinding":{"concern":7,"no_effect":3,"mixed":0},"gap":{"independent":{"concern":4,"total":5},"industry":{"concern":0,"total":0}},"fundingSources":{"full_text":4,"grant_metadata":5,"abstract":0,"none":1},"newestPublished":"2026-10-01","papers":[{"id":"pmid:42913542","pmid":"42913542","pmcid":"PMC13674247","doi":"10.1021/jacs.6c11635","title":"Calcium Metal Mechanochemically Defluorinates PFAS to Environmentally Benign CaF2.","journal":"Journal of the American Chemical Society","published":"2026-10-01","design":"other","finding":"no_effect","summary":"Calcium metal mechanochemically defluorinates PTFE and PFOA at ambient starting temperature, sequestering fluorine as benign, insoluble calcium fluoride.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"HORIZON EUROPE\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42861112","pmid":"42861112","pmcid":"","doi":"10.1016/j.eehl.2026.100285","title":"Polytetrafluoroethylene utensils as a source of micro- and nanoplastics: Insights from a <i>Drosophila</i> model.","journal":"Eco-Environment & Health","published":"2026-09-15","design":"animal","finding":"concern","summary":"Oral exposure to polytetrafluoroethylene micro- and nanoplastics in Drosophila caused gut damage, oxidative stress, mitochondrial dysfunction, DNA damage, and widespread gene expression alterations.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42896322","pmid":"42896322","pmcid":"","doi":"10.1016/j.jhazmat.2026.143575","title":"Material-specific modulation of microplastic biotoxicity by chlorination: Mechanistic insights into ER stress and associated health risks.","journal":"Journal of hazardous materials","published":"2026-09-11","design":"animal","finding":"concern","summary":"Chlorination induced physicochemical changes across four microplastics, including PTFE, with detailed evaluation of toxicity and endoplasmic reticulum stress pathways in vitro and in vivo.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42710316","pmid":"42710316","pmcid":"","doi":"10.1016/j.marpolbul.2026.120286","title":"Spatial distribution, characteristics, polymer composition, and ecological risk of microplastics in marine sediments of Central Vietnam.","journal":"Marine pollution bulletin","published":"2026-09-08","design":"other","finding":"concern","summary":"Microplastics including PTFE were detected across marine sediments in Central Vietnam, with polymer hazard and ecological risk indices reaching the highest risk level.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42669748","pmid":"42669748","pmcid":"PMC13526814","doi":"10.1038/s41598-026-64337-7","title":"Histological evaluation of pulpal healing following direct pulp capping with polytetrafluoroethylene or melatonin, with or without adjunctive low-level laser therapy in Wistar rat molars.","journal":"Scientific reports","published":"2026-08-30","design":"animal","finding":"no_effect","summary":"Direct pulp capping with polytetrafluoroethylene or melatonin, with or without low-level laser therapy, was histologically assessed for pulpal healing in Wistar rat molars.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"full_text","verified":false},{"id":"pmid:42580107","pmid":"42580107","pmcid":"","doi":"10.1016/j.jhazmat.2026.143246","title":"Microplastics as an environmental driver of impaired nutrition.","journal":"Journal of hazardous materials","published":"2026-08-07","design":"in_vitro","finding":"concern","summary":"PTFE and HDPE plastic particles adsorb dietary proteins and lipids under gastrointestinal conditions and impair nutrient absorption in vitro.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Horizon 2020\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42589858","pmid":"42589858","pmcid":"PMC13468768","doi":"10.3390/polym18151929","title":"Thermal Depolymerization Challenges of PTFE:Silicone Rubber Mixtures and Composite Materials.","journal":"Polymers","published":"2026-08-06","design":"other","finding":"concern","summary":"Co-pyrolysis of PTFE and silicone rubber mixtures forms fluorinated siloxanes and per- and polyfluoroalkyl substances, complicating depolymerization-based recycling.","funding":"unclear","conflictOfInterest":true,"fundingEvidence":["COI: \"employed by\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42919297","pmid":"42919297","pmcid":"PMC13693164","doi":"10.1186/s12886-026-05154-4","title":"The effect of polytetrafluoroethylene on different ocular tissues.","journal":"BMC ophthalmology","published":"2026-07-27","design":"animal","finding":"no_effect","summary":"PTFE pieces implanted into rabbit anterior chambers and vitreous cavities caused no significant inflammatory or toxic histopathological effects in ocular tissues after one month.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"full_text","verified":false},{"id":"pmid:42162722","pmid":"42162722","pmcid":"","doi":"10.1016/j.envres.2026.124803","title":"First biomonitoring of micro/nanoplastic pollution in freshwater fish from Yalong River, China: accumulation dynamics, influencing factors and ecological risk.","journal":"Environmental research","published":"2026-05-19","design":"other","finding":"concern","summary":"Biomonitoring of Yalong River fish revealed polytetrafluoroethylene (PTFE) as the dominant microplastic polymer, with microplastic abundance negatively correlated with body size and associated with ecological risks.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"National Natural Science Foundation of China\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42086804","pmid":"42086804","pmcid":"PMC13379464","doi":"10.1007/s00204-026-04417-9","title":"Real-life nanoplastics induce endothelial dysfunction in primary human endothelial cells.","journal":"Archives of toxicology","published":"2026-05-05","design":"in_vitro","finding":"concern","summary":"Exposure to polytetrafluoroethylene nanoplastics in primary human umbilical vein endothelial cells impaired cell migration and reduced wound closure without causing cytotoxicity or DNA damage.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"European Union\""],"fundingSource":"full_text","verified":false}],"substitution":{"claim":"PFOA-free","original":{"label":"PFOA","papers":7471},"replacements":[{"label":"GenX","papers":624},{"label":"PFBS","papers":1013}]},"model":"gemini-3.8-flash","run":{"aiCalls":40,"cachedPapers":0,"offTopic":30,"inputTokens":27479,"outputTokens":5045}}