{"v":1,"ledgerId":"retinyl-palmitate","generatedAt":"2026-11-05T21:43:23.211Z","query":"(TITLE:(\"Retinyl Palmitate\" OR \"RETINYL PALMITATE\" OR \"RETINYL ACETATE\" OR \"79-81-2\") OR ABSTRACT:(\"Retinyl Palmitate\" OR \"RETINYL PALMITATE\" OR \"RETINYL ACETATE\" OR \"79-81-2\")) AND (TOXICITY OR EXPOSURE OR \"ENDOCRINE\" OR \"REPRODUCTIVE\" OR CARCINOGEN* OR \"BIOMONITORING\" OR \"SYSTEMATIC REVIEW\") AND SRC:MED AND LANG:eng","totalPapers":469,"lastYearPapers":6,"analysed":18,"byFunding":{"independent":11,"industry":0,"mixed":0,"none_declared":0,"unclear":7},"byDesign":{"human":4,"animal":6,"in_vitro":4,"review":3,"other":1},"byFinding":{"concern":4,"no_effect":12,"mixed":2},"gap":{"independent":{"concern":2,"total":11},"industry":{"concern":0,"total":0}},"fundingSources":{"full_text":12,"grant_metadata":2,"abstract":0,"none":4},"newestPublished":"2026-03-13","papers":[{"id":"pmid:41899112","pmid":"41899112","pmcid":"PMC13027102","doi":"10.3390/jcm15062185","title":"Microneedling and Topical Retinyl Palmitate for Acne Scars: A Preliminary Split-Face Study with Placebo Control.","journal":"Journal of clinical medicine","published":"2026-03-13","design":"human_rct","finding":"no_effect","summary":"A split-face study found no significant differences in acne scar reduction or side effects between microneedling combined with 5% retinyl palmitate oleogel versus microneedling with placebo.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University\""],"fundingSource":"full_text","verified":false},{"id":"pmid:41597238","pmid":"41597238","pmcid":"PMC12839226","doi":"10.3390/cells15020163","title":"Tracking Systemic and Ocular Vitamin A.","journal":"Cells","published":"2026-01-16","design":"animal","finding":"no_effect","summary":"Dietary or intraperitoneal retinyl palmitate elevated plasma and liver retinoid stores in mice, while light exposure modulated ocular retinoid and bisretinoid levels.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"NIH\""],"fundingSource":"full_text","verified":false},{"id":"pmid:41109574","pmid":"41109574","pmcid":"","doi":"10.1016/j.jnutbio.2025.110149","title":"Vitamin A supplementation during the suckling period attenuates the effects of a maternal Western diet on liver sexual maturity-related traits in a sex-dependent manner.","journal":"The Journal of nutritional biochemistry","published":"2025-10-16","design":"animal","finding":"no_effect","summary":"Retinyl palmitate supplementation during suckling counteracted maternal Western diet-induced alterations in liver puberty-related gene expression in male mouse offspring.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:41057405","pmid":"41057405","pmcid":"PMC12504743","doi":"10.1038/s41598-025-18896-w","title":"Perinatal vitamin A excess impacts vitamin A and lipid metabolism in rat offspring.","journal":"Scientific reports","published":"2025-10-07","design":"animal","finding":"concern","summary":"Perinatal high-dose vitamin A supplementation in rats resulted in hepatic vitamin A accumulation and disrupted lipid metabolism in offspring.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"INRAE\""],"fundingSource":"full_text","verified":false},{"id":"pmid:40612304","pmid":"40612304","pmcid":"PMC12224656","doi":"10.3389/fnut.2025.1609759","title":"Do serum vitamins, carotenoids, and retinyl esters influence mortality in osteoarthritis? Insights from a nationally representative study.","journal":"Frontiers in nutrition","published":"2025-06-19","design":"human_cohort","finding":"no_effect","summary":"In a cohort of osteoarthritis patients, higher serum retinyl palmitate levels were associated with a reduced risk of all-cause and cancer-related mortality.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University of Chinese Medicine (Grant Nos. 2022XYLH045 and 2022XYLH055), and the Graduate Innovation Project of Hunan University of Chinese Medicine (Grant\""],"fundingSource":"full_text","verified":false},{"id":"pmid:40535913","pmid":"40535913","pmcid":"PMC12174659","doi":"10.1002/fsn3.70463","title":"Evaluation of Oxidative Stability and Quality Parameters of Sunflower Oil Enriched With Different Levels of Retinyl Palmitate Under Different Storage Conditions.","journal":"Food science & nutrition","published":"2025-06-18","design":"other","finding":"mixed","summary":"Light exposure, storage time, and bottle color significantly affected the oxidative stability and degradation of retinyl palmitate in fortified sunflower oil.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:40343007","pmid":"40343007","pmcid":"PMC12058701","doi":"10.3389/fphar.2025.1562244","title":"Synergistic effects of retinol and retinyl palmitate in alleviating UVB-induced DNA damage and promoting the homologous recombination repair in keratinocytes.","journal":"Frontiers in pharmacology","published":"2025-04-24","design":"in_vitro","finding":"no_effect","summary":"Retinol and retinyl palmitate combined after UVB exposure reduced DNA damage, inflammation, and apoptosis, while promoting homologous recombination repair in human keratinocytes and reconstructed epidermis.","funding":"unclear","conflictOfInterest":true,"fundingEvidence":["COI: \"employed by\""],"fundingSource":"full_text","verified":false},{"id":"pmid:40305237","pmid":"40305237","pmcid":"PMC12024622","doi":"10.3390/biom15040540","title":"Randomized Controlled Clinical Trial of Pediatric Pneumococcus and Hepatitis A Vaccinations With or Without a High-Dose Oral Vitamin A Supplement.","journal":"Biomolecules","published":"2025-04-07","design":"human_rct","finding":"concern","summary":"High-dose retinyl palmitate supplementation provided no immune benefit in vaccinated children and showed a trend toward weaker vaccine responses in participants with high baseline retinol.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"NIH\""],"fundingSource":"full_text","verified":false},{"id":"pmid:38203675","pmid":"38203675","pmcid":"PMC10779001","doi":"10.3390/ijms25010506","title":"Scavenging of Cation Radicals of the Visual Cycle Retinoids by Lutein, Zeaxanthin, Taurine, and Melanin.","journal":"International journal of molecular sciences","published":"2023-12-29","design":"in_vitro","finding":"no_effect","summary":"Pulse radiolysis determined rate constants for antioxidant scavenging of visual cycle retinoid cation radicals, including retinol and retinyl palmitate.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"European Union\""],"fundingSource":"full_text","verified":false},{"id":"pmid:38001766","pmid":"38001766","pmcid":"PMC10669859","doi":"10.3390/antiox12111913","title":"Super-Antioxidant Vitamin A Derivatives with Improved Stability and Efficacy Using Skin-Permeable Chitosan Nanocapsules.","journal":"Antioxidants (Basel, Switzerland)","published":"2023-10-26","design":"in_vitro","finding":"no_effect","summary":"Chitosan-coated nanocapsules encapsulating retinyl palmitate improved stability and skin penetration, showing antioxidant effects, collagen synthesis, and cell proliferation without cytotoxicity in dermal fibroblasts.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"government\""],"fundingSource":"full_text","verified":false},{"id":"pmid:37927602","pmid":"37927602","pmcid":"PMC10622759","doi":"10.3389/fphar.2023.1278838","title":"Efficacy and mechanism of retinyl palmitate against UVB-induced skin photoaging.","journal":"Frontiers in pharmacology","published":"2023-10-20","design":"in_vitro","finding":"no_effect","summary":"Retinyl palmitate reduced collagen degradation, apoptosis, and inflammatory cytokine expression induced by UVB radiation in skin cells.","funding":"unclear","conflictOfInterest":true,"fundingEvidence":["COI: \"employed by\""],"fundingSource":"full_text","verified":false},{"id":"pmid:37760056","pmid":"37760056","pmcid":"PMC10525582","doi":"10.3390/antiox12091753","title":"Antioxidant Use after Diagnosis of Head and Neck Squamous Cell Carcinoma (HNSCC): A Systematic Review of Application during Radiotherapy and in Second Primary Cancer Prevention.","journal":"Antioxidants (Basel, Switzerland)","published":"2023-09-12","design":"systematic_review","finding":"no_effect","summary":"A systematic review found that retinyl palmitate and other antioxidants were not effective in preventing second primary tumors in head and neck squamous cell carcinoma patients.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University\""],"fundingSource":"full_text","verified":false},{"id":"pmid:37608385","pmid":"37608385","pmcid":"PMC10464232","doi":"10.1186/s13643-023-02294-2","title":"Comparative efficacy of oral drugs for chronic radiation proctitis - a systematic review.","journal":"Systematic reviews","published":"2023-08-22","design":"systematic_review","finding":"no_effect","summary":"A systematic review of treatments for chronic radiation proctitis found that oral retinyl palmitate reduced rectal bleeding.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Provincial\""],"fundingSource":"full_text","verified":false},{"id":"pmid:37375657","pmid":"37375657","pmcid":"PMC10302570","doi":"10.3390/nu15122754","title":"Assessing the Interactions between Zinc and Vitamin A on Intestinal Functionality, Morphology, and the Microbiome In Vivo (Gallus gallus).","journal":"Nutrients","published":"2023-06-15","design":"animal","finding":"no_effect","summary":"Intra-amniotic administration of zinc and retinyl palmitate in Gallus gallus modulated intestinal gene expression, morphology, and gut bacterial populations.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University\""],"fundingSource":"full_text","verified":false},{"id":"pmid:36774779","pmid":"36774779","pmcid":"PMC9945759","doi":"10.1016/j.redox.2023.102619","title":"ROS-lowering doses of vitamins C and A accelerate malignant melanoma metastasis.","journal":"Redox biology","published":"2023-02-02","design":"animal","finding":"concern","summary":"Retinyl palmitate and other ROS-lowering antioxidants accelerated melanoma cell migration and metastasis in mice through BACH1 activation.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:36178059","pmid":"36178059","pmcid":"","doi":"10.1093/jn/nxac227","title":"Total Liver Vitamin A Reserves, Determined With 13C2-Retinol Isotope Dilution, are Similar Among Tanzanian Preschool Children in Areas With Low and High Vitamin A Exposure.","journal":"The Journal of nutrition","published":"2023-01-01","design":"human_cross_sectional","finding":"no_effect","summary":"Total liver vitamin A reserves did not differ significantly between children in low- and high-exposure intervention areas, and no hypervitaminosis A was observed.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:36496428","pmid":"36496428","pmcid":"PMC9735279","doi":"10.1038/s41598-022-23919-x","title":"Influence of Vitamin A supplementation on inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials.","journal":"Scientific reports","published":"2022-12-10","design":"systematic_review","finding":"mixed","summary":"A meta-analysis of randomized controlled trials found vitamin A supplementation increased CRP levels in adults, while decreasing IL-6 at high doses and TNF-α in chronic hepatitis B patients.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:36200141","pmid":"36200141","pmcid":"","doi":"10.1024/0300-9831/a000769","title":"Adverse effects of maternal retinyl palmitate, a vitamin A compound, on the fetal liver.","journal":"International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologi","published":"2022-10-06","design":"animal","finding":"concern","summary":"Maternal oral administration of retinyl palmitate at doses exceeding 10,000 IU/kg reduced fetal liver volume, hepatocyte count, and proliferation while increasing apoptosis in rats.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false}],"model":"gemini-3.8-flash","run":{"aiCalls":40,"cachedPapers":0,"offTopic":22,"inputTokens":27612,"outputTokens":5290}}