{"v":1,"ledgerId":"sodium-borate","generatedAt":"2026-11-05T22:36:03.800Z","query":"(TITLE:(\"Boric Acid\" OR \"BORIC ACID\" OR \"SODIUM BORATE\" OR \"DISODIUM TETRABORATE\" OR \"10043-35-3\") OR ABSTRACT:(\"Boric Acid\" OR \"BORIC ACID\" OR \"SODIUM BORATE\" OR \"DISODIUM TETRABORATE\" OR \"10043-35-3\")) AND (TOXICITY OR EXPOSURE OR \"ENDOCRINE\" OR \"REPRODUCTIVE\" OR CARCINOGEN* OR \"BIOMONITORING\" OR \"SYSTEMATIC REVIEW\") AND SRC:MED AND LANG:eng","totalPapers":858,"lastYearPapers":81,"analysed":18,"byFunding":{"independent":9,"industry":0,"mixed":0,"none_declared":2,"unclear":7},"byDesign":{"human":0,"animal":9,"in_vitro":6,"review":0,"other":3},"byFinding":{"concern":8,"no_effect":8,"mixed":2},"gap":{"independent":{"concern":5,"total":9},"industry":{"concern":0,"total":0}},"fundingSources":{"full_text":9,"grant_metadata":4,"abstract":0,"none":5},"newestPublished":"2026-09-22","papers":[{"id":"pmid:42772397","pmid":"42772397","pmcid":"","doi":"10.1016/j.actatropica.2026.108337","title":"Comparative efficacy of nano-formulated toxic sugar baits (Nano-TSBs) combining Datura stramonium L.+ivermectin and Azadirachta indica A. Juss+boric acid against Aedes aegypti Linnaeus, Anopheles stephensi Liston, and Culex quinquefasciatus Say (Diptera: Culicidae) and their effects upon non-target ","journal":"Acta tropica","published":"2026-09-22","design":"animal","finding":"concern","summary":"Azadirachta indica combined with boric acid in nano-sugar baits suppressed mosquito fecundity and caused abnormal behavior and mortality in tested non-target insects.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42792814","pmid":"42792814","pmcid":"PMC13604345","doi":"10.3390/biomedicines14092073","title":"Differential Effects of Carboplatin, Metformin, and Boric Acid on Cell Viability, Migration, and Oxidative Stress in MCF-7 Breast Cancer and CRL-4010 Normal Mammary Epithelial Cells.","journal":"Biomedicines","published":"2026-09-15","design":"in_vitro","finding":"concern","summary":"Boric acid, alone and in combination with carboplatin and metformin, altered cell viability, migration, and superoxide dismutase activity in human breast cancer and normal mammary epithelial cells.","funding":"none_declared","conflictOfInterest":false,"fundingEvidence":["none: \"This research received no\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42739347","pmid":"42739347","pmcid":"PMC13567620","doi":"10.3390/plants15172580","title":"Zinc Fertilization Mitigates Boron Toxicity in <i>Citrus</i>: Plant Growth, Tissue Mineral Composition and Antioxidant Enzyme Activity.","journal":"Plants (Basel, Switzerland)","published":"2026-08-24","design":"other","finding":"concern","summary":"Excess boric acid induced toxicity symptoms, impaired photosynthesis, and disrupted mineral nutrient profiles and antioxidant enzyme activities in Citrus seedlings, which was partially mitigated by zinc.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"National Natural Science Foundation of China\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42623128","pmid":"42623128","pmcid":"","doi":"10.1093/etojnl/vgag230","title":"Assessing the suitability of alternative organic matter materials for peat replacement in standard artificial soil formulations.","journal":"Environmental toxicology and chemistry","published":"2026-08-20","design":"animal","finding":"concern","summary":"Earthworms were exposed to boric acid in artificial soils formulated with alternative organic matter materials to derive toxicity benchmarks.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42791532","pmid":"42791532","pmcid":"PMC13613850","doi":"10.1186/s12870-026-09638-9","title":"Foliar application of nanoboron fertilizer at different growth stages enhanced the nutrient use efficiency of cauliflower, leading to improve productivity, quality, and profitability.","journal":"BMC plant biology","published":"2026-07-30","design":"other","finding":"no_effect","summary":"Foliar application of boron nanoparticles and conventional boric acid was evaluated on cauliflower, with 200 ppm nanoboron improving curd yield, quality parameters, and nutrient uptake efficiency.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42652440","pmid":"42652440","pmcid":"PMC13513199","doi":"10.3390/insects17080785","title":"Behavioral Effects of Low Concentrations of Boric Acid and Thiamethoxam Baits on the Laboratory Colonies of the Argentine Ant.","journal":"Insects","published":"2026-07-29","design":"animal","finding":"concern","summary":"Low concentrations of boric acid bait increased in-nest aggregation and reduced activity in the foraging area of laboratory Argentine ant colonies.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Institute of\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42477061","pmid":"42477061","pmcid":"PMC13385873","doi":"10.1038/s41598-026-52829-5","title":"Comparative antibacterial efficacy of calcium hydroxide, diclofenac sodium, chitosan, and boric acid against Enterococcus faecalis: an in vitro study.","journal":"Scientific reports","published":"2026-07-20","design":"in_vitro","finding":"no_effect","summary":"Boric acid intracanal medicament significantly reduced Enterococcus faecalis counts in inoculated extracted teeth by 67.10% after seven days.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"full_text","verified":false},{"id":"pmid:42426074","pmid":"42426074","pmcid":"","doi":"10.1038/s41598-026-59115-4","title":"Optimizing sowing time and foliar boron application improves soil moisture use, physiological efficiency, and yield stability of field pea (Pisum sativum L.) in rainfed rice-fallow systems.","journal":"Scientific reports","published":"2026-07-09","design":"other","finding":"no_effect","summary":"Foliar boric acid application improved physiological traits, pollen viability, and grain yield in field peas grown in rainfed rice-fallow systems.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42426544","pmid":"42426544","pmcid":"","doi":"10.1007/s12011-026-05219-x","title":"Effect of Boron on the Growth Performance, Biochemical Indices, Carcass, Intestinal and Bone Characteristics with Economics in Broiler Chickens.","journal":"Biological trace element research","published":"2026-07-09","design":"animal","finding":"no_effect","summary":"Dietary boric acid supplementation up to 48 ppm improved growth performance, serum biochemical profiles, and intestinal and bone characteristics in broiler chickens.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42574523","pmid":"42574523","pmcid":"","doi":"10.1093/jme/tjag132","title":"Lethal and sublethal effects of toxic sugar baits differ among insecticide resistant and insecticide susceptible populations of Aedes aegypti.","journal":"Journal of medical entomology","published":"2026-07-01","design":"animal","finding":"concern","summary":"Boric acid and dinotefuran toxic sugar bait exposure increased mortality, reduced blood feeding, and resistance-dependently altered ingestion and fertility in Aedes aegypti.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Institute of\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42349090","pmid":"42349090","pmcid":"","doi":"10.1016/j.ejogrb.2026.115268","title":"Boric acid Attenuates premature ovarian insufficiency by Modulating oxidative stress in a Cyclophosphamide-Induced rat model.","journal":"European journal of obstetrics, gynecology, and reproductive biology","published":"2026-06-21","design":"animal","finding":"no_effect","summary":"Boric acid partially attenuated cyclophosphamide-induced ovarian damage and modulated oxidative stress markers in female Wistar-Albino rats.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42296279","pmid":"42296279","pmcid":"PMC13580430","doi":"10.1002/lsm.70164","title":"Evaluation of the Efficacy of Photobiomodulation Therapy, Therapeutic Ultrasound, and Boric Acid in the Prevention of Intra-Abdominal Adhesions in an Experimental Rat Model: A Macroscopic, Histopathological, and Gene Expression Analysis.","journal":"Lasers in surgery and medicine","published":"2026-06-15","design":"animal","finding":"concern","summary":"Intraperitoneal boric acid showed limited efficacy in preventing induced intra-abdominal adhesions in rats and was associated with increased oxidative stress and inflammatory responses.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Research Council\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42346545","pmid":"42346545","pmcid":"PMC13302383","doi":"10.3390/jof12060415","title":"Efficacies of Conventional Antifungals and Complementary and Alternative Medicine as Single or Combination Therapies Against <i>Candida</i> Biofilms in Recurrent Vaginal Candidiasis: An In Vitro Study.","journal":"Journal of fungi (Basel, Switzerland)","published":"2026-06-08","design":"in_vitro","finding":"no_effect","summary":"Boric acid and other tested agents demonstrated efficacy against planktonic Candida cells but showed limited activity against Candida biofilms in vitro.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Ministry of\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42347210","pmid":"42347210","pmcid":"PMC13304812","doi":"10.3390/pathogens15060598","title":"In Vitro Antibacterial and Antibiofilm Effects of Antiseptics and Mouthwashes on <i>Streptococcus mutans</i>.","journal":"Pathogens (Basel, Switzerland)","published":"2026-06-02","design":"in_vitro","finding":"mixed","summary":"Boric acid exhibited variable in vitro antibacterial and antibiofilm activity against planktonic and biofilm forms of Streptococcus mutans.","funding":"none_declared","conflictOfInterest":true,"fundingEvidence":["none: \"This research received no\"","COI: \"employed by\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42223303","pmid":"42223303","pmcid":"","doi":"10.1002/cbin.70171","title":"Cell Line-Specific In Vitro Effects of Boric Acid and Meis1i-2 in Leukemia Cells: Apoptosis, Cell-Cycle Modulation, and Fixed-Dose Interaction.","journal":"Cell biology international","published":"2026-06-01","design":"in_vitro","finding":"mixed","summary":"Boric acid and Meis1i-2 altered viability, induced apoptosis, and modulated cell-cycle dynamics in leukemia cell lines, exhibiting concentration-dependent effects and an antagonistic combination in RS4-11 cells.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42395670","pmid":"42395670","pmcid":"PMC13324418","doi":"10.5527/wjn.v15.i2.116474","title":"Protective effect of boric acid on kidney tissue and oxidative stress after testicular torsion/detorsion in male rats.","journal":"World journal of nephrology","published":"2026-06-01","design":"animal","finding":"no_effect","summary":"Boric acid administered intraperitoneally reduced oxidative stress and histopathological kidney damage induced by testicular torsion/detorsion in male rats.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42178444","pmid":"42178444","pmcid":"PMC13437609","doi":"10.1007/s12011-026-05158-7","title":"Targeting the SOX11/GPX4/SLC7A11 Axis: A Novel Mechanism for Boric Acid-Induced Ferroptosis in Endometrial Cancer.","journal":"Biological trace element research","published":"2026-05-25","design":"in_vitro","finding":"concern","summary":"Boric acid reduced cell viability and induced ferroptosis in human endometrial cancer cells through downregulation of SOX11, GPX4, and SLC7A11.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Research Council\""],"fundingSource":"full_text","verified":false},{"id":"pmid:42087024","pmid":"42087024","pmcid":"PMC13437559","doi":"10.1007/s12011-026-05138-x","title":"The Effects of Boron Mineral on Performance, Bone and Mineral Metabolism in Purebred Arabian Foals.","journal":"Biological trace element research","published":"2026-05-06","design":"animal","finding":"no_effect","summary":"Dietary boric acid supplementation up to 15 mg/day improved growth performance and bone and mineral metabolism in Purebred Arabian foals without adverse effects.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University Open access funding provided by the Scientific and Technological Research Council of Türkiye (TÜBİTAK). Open access fund\""],"fundingSource":"full_text","verified":false}],"model":"gemini-3.8-flash","run":{"aiCalls":38,"cachedPapers":0,"offTopic":20,"inputTokens":26673,"outputTokens":4730}}