{"v":1,"ledgerId":"styrene-ps6","generatedAt":"2026-11-05T22:23:47.490Z","query":"(TITLE:(\"Styrene Monomer\" OR \"STYRENE\" OR \"100-42-5\") OR ABSTRACT:(\"Styrene Monomer\" OR \"STYRENE\" OR \"100-42-5\")) AND (TOXICITY OR EXPOSURE OR \"ENDOCRINE\" OR \"REPRODUCTIVE\" OR CARCINOGEN* OR \"BIOMONITORING\" OR \"SYSTEMATIC REVIEW\") AND SRC:MED AND LANG:eng","totalPapers":3710,"lastYearPapers":279,"analysed":6,"byFunding":{"independent":4,"industry":0,"mixed":0,"none_declared":0,"unclear":2},"byDesign":{"human":1,"animal":1,"in_vitro":1,"review":0,"other":3},"byFinding":{"concern":5,"no_effect":1,"mixed":0},"gap":{"independent":{"concern":3,"total":4},"industry":{"concern":0,"total":0}},"fundingSources":{"full_text":1,"grant_metadata":4,"abstract":0,"none":1},"newestPublished":"2026-10-30","papers":[{"id":"pmid:42959001","pmid":"42959001","pmcid":"","doi":"10.1002/jat.70487","title":"Estimation of Dermal Uptake of Airborne Volatile Organic Compounds (VOCs) Using a Passive Sampler With Porcine Skin Membrane.","journal":"Journal of applied toxicology : JAT","published":"2026-10-30","design":"in_vitro","finding":"concern","summary":"A porcine skin membrane model demonstrated dermal absorption of airborne volatile organic compounds including styrene, showing dynamic diffusion-volatilization equilibrium and associated epidermal damage.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"Ministry of\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42868710","pmid":"42868710","pmcid":"","doi":"10.1016/j.ecoenv.2026.120909","title":"Personal VOC exposure in a multi-source open-air mass gathering environment: An integrated passive air and biomonitoring study.","journal":"Ecotoxicology and environmental safety","published":"2026-10-13","design":"human_cohort","finding":"concern","summary":"Personal air concentrations of styrene and urinary levels of its metabolites increased significantly among 30 participants during a university festival.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42872670","pmid":"42872670","pmcid":"","doi":"10.2174/0109298673522628261007063935","title":"A Combined Network Toxicology and Docking Study to Identify Putative Molecular Targets Linking Styrene Exposure to Atherosclerosis.","journal":"Current medicinal chemistry","published":"2026-10-12","design":"other","finding":"concern","summary":"A computational network toxicology and molecular docking study identified CCND3 and inflammatory pathways as putative targets linking styrene exposure to atherosclerosis.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42778014","pmid":"42778014","pmcid":"","doi":"10.1016/j.envpol.2026.129171","title":"Vertical distribution and health risk assessment of SBTEX in urban microenvironments: A comparative study between parking and high-rise buildings areas during haze and non-haze periods.","journal":"Environmental pollution (Barking, Essex : 1987)","published":"2026-09-23","design":"other","finding":"no_effect","summary":"Air monitoring in Chiang Mai found vertical variation in SBTEX concentrations and negligible non-carcinogenic health risks for ground-level staff.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"University\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42784882","pmid":"42784882","pmcid":"","doi":"10.1016/j.envint.2026.110529","title":"Plastic button manufacturing as an under-recognized source of airborne multi-pollutant mixtures: process-resolved characterization and potential health risk.","journal":"Environment international","published":"2026-09-20","design":"other","finding":"concern","summary":"Airborne monitoring in a plastic button manufacturing facility identified styrene as a dominant volatile organic compound contributing to elevated nervous-system hazard indices.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:41693466","pmid":"41693466","pmcid":"PMC12915766","doi":"10.1080/19490976.2026.2630481","title":"Novel bacterium <i>Enterocloster</i> sp. M3 promotes colorectal tumorigenesis via the production of the carcinogen styrene.","journal":"Gut microbes","published":"2026-02-16","design":"animal","finding":"concern","summary":"Enterocloster sp. M3 directly biosynthesizes styrene, which is elevated in colorectal cancer patient feces and promotes colorectal tumor development in mice.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"National Natural Science Foundation of China\""],"fundingSource":"full_text","verified":false}],"model":"gemini-3.8-flash","run":{"aiCalls":40,"cachedPapers":0,"offTopic":33,"inputTokens":26321,"outputTokens":4816}}