{"v":1,"ledgerId":"talc","generatedAt":"2026-11-05T22:42:41.544Z","query":"(TITLE:(\"Talc\" OR \"TALC\" OR \"HYDRATED MAGNESIUM SILICATE\" OR \"CI 77718\" OR \"14807-96-6\") OR ABSTRACT:(\"Talc\" OR \"TALC\" OR \"HYDRATED MAGNESIUM SILICATE\" OR \"CI 77718\" OR \"14807-96-6\")) AND (TOXICITY OR EXPOSURE OR \"ENDOCRINE\" OR \"REPRODUCTIVE\" OR CARCINOGEN* OR \"BIOMONITORING\" OR \"SYSTEMATIC REVIEW\") AND SRC:MED AND LANG:eng","totalPapers":753,"lastYearPapers":64,"analysed":11,"byFunding":{"independent":1,"industry":0,"mixed":0,"none_declared":0,"unclear":10},"byDesign":{"human":1,"animal":0,"in_vitro":0,"review":3,"other":7},"byFinding":{"concern":0,"no_effect":7,"mixed":4},"gap":{"independent":{"concern":0,"total":1},"industry":{"concern":0,"total":0}},"fundingSources":{"full_text":2,"grant_metadata":1,"abstract":0,"none":8},"newestPublished":"2026-11-01","papers":[{"id":"pmid:42578967","pmid":"42578967","pmcid":"PMC13573239","doi":"10.1158/1055-9965.epi-26-0751","title":"Personal Talc Use and Incident Lung Cancer.","journal":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive ","published":"2026-11-01","design":"human_cohort","finding":"mixed","summary":"In a cohort of 49,592 women, personal talc use was not consistently associated with incident lung cancer overall, though suggestive positive associations were noted among never-smokers and for adenocarcinomas.","funding":"independent","conflictOfInterest":false,"fundingEvidence":["public: \"National Institute of Environmental Health\""],"fundingSource":"grant_metadata","verified":false},{"id":"pmid:42956018","pmid":"42956018","pmcid":"PMC13718977","doi":"10.1371/journal.pone.0361817","title":"Gynecological malignancy signal triage: A two-dimensional framework integrating US-derived FAERS data with comparative US-China GBD trajectories.","journal":"PloS one","published":"2026-10-29","design":"other","finding":"mixed","summary":"Talc showed marked statistical disproportionality for cancer-related adverse event reports in FAERS, though reporter and temporal features suggested stimulated reporting.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"full_text","verified":false},{"id":"pmid:42833996","pmid":"42833996","pmcid":"","doi":"10.1002/cnr2.70705","title":"Talc Use and Risk of Cancer: An Umbrella Review and Overlapped Analysis.","journal":"Cancer reports (Hoboken, N.J.)","published":"2026-10-01","design":"systematic_review","finding":"mixed","summary":"An umbrella review found suggestive associations between cosmetic talc and ovarian cancer and occupational exposure and colorectal cancer, but overall confidence in the included reviews was limited.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42373004","pmid":"42373004","pmcid":"","doi":"10.1016/j.yrtph.2026.106169","title":"The NTP chronic inhalation study does not support an inherent lung cancer hazard of talc: Implications of lung particle overload and maximum tolerated dose.","journal":"Regulatory toxicology and pharmacology : RTP","published":"2026-06-29","design":"other","finding":"no_effect","summary":"Re-analysis of NTP inhalation data indicates that rat lung tumors occurred only under conditions of particle overload exceeding the maximum tolerated dose rather than representing an inherent carcinogenic hazard.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42363609","pmid":"42363609","pmcid":"","doi":"10.1080/08958378.2026.2689661","title":"A Monte Carlo simulation for evaluating hypothetical mesothelioma risk in a person exposed to talcum powder.","journal":"Inhalation toxicology","published":"2026-06-26","design":"other","finding":"no_effect","summary":"A Monte Carlo simulation estimated that hypothetical airborne exposure to talcum powder yields an excess lifetime mesothelioma risk below the U.S. EPA benchmark.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:42192949","pmid":"42192949","pmcid":"PMC13204818","doi":"10.3390/cancers18101589","title":"Talc Exposure and Risk of Ovarian Cancer: A Systematic Review and Meta-Analysis with Limited Evidence on Cervical and Endometrial Cancers.","journal":"Cancers","published":"2026-05-13","design":"systematic_review","finding":"mixed","summary":"A meta-analysis found perineal talc use associated with increased ovarian cancer risk in case-control studies, but cohort studies showed no significant association.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"full_text","verified":false},{"id":"pmid:41967769","pmid":"41967769","pmcid":"","doi":"10.1016/j.jtho.2026.103710","title":"Occupational Exposure to Asbestos-Free Talc and Risk of Respiratory Cancers, Including Larynx, Lung, and Mesothelioma: A Systematic Review and Meta-Analysis.","journal":"Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer","published":"2026-04-10","design":"systematic_review","finding":"no_effect","summary":"A systematic review and meta-analysis found that occupational exposure to asbestos-free talc was not associated with increased risks of lung, mesothelioma, or laryngeal cancers.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:41687805","pmid":"41687805","pmcid":"","doi":"10.1016/j.yrtph.2026.106060","title":"Talc fits the framework of poorly soluble low-toxicity particles - implications for hazard classification.","journal":"Regulatory toxicology and pharmacology : RTP","published":"2026-02-11","design":"other","finding":"no_effect","summary":"Review indicates talc exhibits properties of poorly soluble low-toxicity particles, with rat lung tumors occurring only under lung overload conditions and no increased lung cancer risk in humans.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:41610408","pmid":"41610408","pmcid":"","doi":"10.1080/15459624.2025.2609708","title":"Airborne dust exposure during the application of talc-based pressed powder makeups.","journal":"Journal of occupational and environmental hygiene","published":"2026-01-29","design":"other","finding":"no_effect","summary":"Application of talc-based pressed powders by regular cosmetic users resulted in low airborne dust levels, suggesting no significant inhalation hazards under normal use conditions.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false},{"id":"pmid:41658396","pmid":"41658396","pmcid":"PMC12874599","doi":"10.1016/j.gloepi.2026.100251","title":"Interpretation of the IARC quantitative bias analysis of talc and ovarian cancer.","journal":"Global epidemiology","published":"2026-01-21","design":"other","finding":"no_effect","summary":"A critique of IARC's quantitative bias analysis argues that exposure misclassification explains case-control associations and epidemiological evidence does not support a link between talc and ovarian cancer.","funding":"unclear","conflictOfInterest":true,"fundingEvidence":["COI: \"employed by\""],"fundingSource":"none","verified":false},{"id":"pmid:41361119","pmid":"41361119","pmcid":"","doi":"10.1007/s00204-025-04253-3","title":"Pheochromocytoma in rats: a weak link in the assessment of talc carcinogenicity?","journal":"Archives of toxicology","published":"2025-12-08","design":"other","finding":"no_effect","summary":"A letter argues that rat pheochromocytoma findings from inhalation studies are irrelevant for assessing human talc carcinogenicity, questioning the IARC reclassification of talc.","funding":"unclear","conflictOfInterest":false,"fundingEvidence":[],"fundingSource":"none","verified":false}],"model":"gemini-3.8-flash","run":{"aiCalls":40,"cachedPapers":0,"offTopic":29,"inputTokens":27375,"outputTokens":5071}}